Journal of Occupational Health and Epidemiology

en Impact of Low-Dose Ionizing Radiation on Liver Function in Mice: A Systematic Review Epidemiology systematic reviews Systematic Reviews <div style="text-align: justify;">Background: Adverse health consequences of exposure to ionizing radiation, especially low-dose radiation (LDR), are highly controversial. Recent studies have shown that ionizing radiation can promote the inflammatory state of the liver. The present study aimed to review the current knowledge of the harmful effects of low-dose ionizing radiation on the liver in mice. Materials and Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science (WOS) databases. The PRISMA protocol was employed for systematic literature review, which includes formulation of research questions, systematic review process for selection of articles, quality assessment, data abstraction, and data analysis. Results: In the first stage of the systematic review process, 1473 articles were retrieved. At last a total of 15 articles were included in the study based on the inclusion and exclusion criteria. LDR from X-rays and gamma rays was utilized for irradiation in these articles. The results revealed that low-dose ionizing radiation can have detrimental effects, including mitochondrial dysfunction, increased oxidative stress, dilation of the central hepatic vein, increased expression of hepatic proteins involved in metabolism, liver inflammation, necrosis, and cancer in the liver. Conclusion: Given the potentially damaging effects of low-dose ionizing radiation exposure to the liver, early identification of individuals at higher risk of exposure to these radiations can result in better preventive intervention decisions to prevent damage.</div> Ionizing Radiation,Low-Dose Radiation,Mice,Gamma Rays,X-Rays,Oxidative Stress, 268 279 http://johe.rums.ac.ir/browse.php?a_code=A-10-497-2&slc_lang=en&sid=1 Behzad Fouladi Dehaghi - - bdehaghi@gmail.com 22400319475328460013391 22400319475328460013391 No Professor, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. - Sara Tabanfar - - tabanfar.s@ajums.ac.ir 22400319475328460013392 22400319475328460013392 No Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. - Seyvan Sobhani - - sobhani.s@ajums.ac.ir 22400319475328460013393 22400319475328460013393 Yes Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. -