Journal of Occupational Health and Epidemiology

en Effectiveness of COVID-19 Vaccination on Disease Severity: A Case-Control Study in Southeast Iran Epidemiology Original Article <div style="text-align: justify;">Background: Given the importance of the effectiveness of vaccination in terms of mitigating the severity of COVID-19 and mortality, knowledge of the effect of the vaccine on the severity of COVID-19 in communities is essential. Thus, the purpose of this study was to ascertain the effect of COVID-19 vaccine on the severity of the COVID-19 in southeastern Iran. Materials and Methods: A case–control study of a total of 1520 adults aged >18 years was conducted in Bam County to assess the association between hospitalizations due to COVID-19 and previous vaccination with existing vaccines (including Sinopharm, AstraZeneca, and CovIran Barkat) in the country. Multinomial logistic regression was employed, and odds ratios (OR) and 95% confidence intervals (CIs) were calculated. Results: After controlling for potential confounders, multinomial logistic regression indicated that COVID-19 vaccination lowered the likelihood of hospitalization for men and women in temporary wards (ORmen=0.22 vs ORwomen=0.34), general wards (ORmen=0.25 vs ORwomen=0.31), and intensive care units (ORmen=0.47 vs ORwomen=0.77) (P<0.001). The odds ratio of hospitalization in all wards diminished for men and women who had received Sinopharm or AstraZeneca and for women who had received the Barkat vaccine, while only a significant difference was detected in the reduction among patients who had received the Sinopharm vaccine (P<0.001). Conclusion: The results revealed that vaccination is related to diminished severity of the disease in the hospital. Thus, efforts to increase the vaccinated population can reduce the severity of COVID-19 and might decreasae the need for intensive care in hospitals.</div> COVID-19 Vaccines,SARS-CoV-2,Hospitalization,Vaccine Efficacy, 240 247 http://johe.rums.ac.ir/browse.php?a_code=A-10-992-1&slc_lang=en&sid=1 Mohsen Mohammadi - - mohsen2019@ymail.com 22400319475328460013469 22400319475328460013469 No Assistant Prof., Dept. of Epidemiology and Biostatics, School of Public Health, Lorestan University of Medical Sciences, Khorramabad, Iran. - Abdolali Golpayegani - - aali.golpa@gmail.com 22400319475328460013470 22400319475328460013470 No Assistant Prof., Dept. of Environmental Health Engineering, School of Public Health, Bam University of Medical Sciences, Bam, Iran. - Fatemeh Doost - Mohammadi - - f.doostmohammadi2@gmail.com 22400319475328460013471 22400319475328460013471 No Ph.D. Student in Epidemiology, Clinical Research Development Unit, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran. Fatemeh Majidpour - - majidpour.fa@gmail.com 22400319475328460013472 22400319475328460013472 No Ph.D Student in Biostatistics, Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. - Elahe Hesari - - elhesari97@gmail.com 22400319475328460013473 22400319475328460013473 No Ph.D. Student in Epidemiology, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. - Maryam Dargahpour - - maryamdargahpour@gmail.com 22400319475328460013474 22400319475328460013474 No M.Sc. in Health Management, School of Public Health, Lorestan University of Medical Sciences, Khorramabad, Iran. Parisa Jalali - - jalalip24@gmail.com 22400319475328460013475 22400319475328460013475 Yes Ph.D. Student in Epidemiology, Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Science, Tehran, Iran. -