en Occupational Health Original Article <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><strong>Background: </strong>The use of psychology in the workplace and accurate scientific findings in this field, in addition to reducing work-related diseases, can promote the performance of employees. Nursing is a stressful job and can be the cause of physical and mental disorders. This study investigates the relationship of personality traits and demographic factors with occupational stress.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><strong>Materials and Methods: </strong>This investigation was a descriptive-correlational study conducted on 95 nurses of hospitals affiliated to Gonabad University of Medical Sciences, Iran, in 2014. The data collection tools used in this study included the Neuroticism-Extraversion-Openness-Five-Factor Inventory (NEO-FFI) and Osipow Occupational Stress Inventory-Revised (OSI-R). Data were analyzed using spearman correlation coefficient, simultaneous multiple regressions and independent t tests in SPSS software.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><strong>Results:</strong> No significant difference was observed between the mean score of occupational stress of men and women undergraduate and master&rsquo;s graduates, and different age groups. The regression model showed that the predictor variables of agreeableness and gender had a significant association with the response variable of occupational stress (P = 0.005). Results showed that the two predictive variables of agreeableness and gender had a negative effect on occupational stress. Nonstandard regression coefficient showed that with 1 unit increase in agreeableness score, the score of occupational stress decreased 1.335 units.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><strong>Conclusions: </strong>There is an association between the agreeableness personality trait and occupational stress. Thus, we recommend that more attention be paid to this feature as a predictor of occupational stress in nurses.</span></p> Personality, Demographic Factor, Stress. 132 139 http://johe.rums.ac.ir/browse.php?a_code=A-10-117-3&slc_lang=en&sid=1 MH Beheshti beheshtihasan8@gmail.com 2240031947532846003914 2240031947532846003914 Yes Faculty Member, Dept. of Occupational Health, Faculty of Health, Gonabad University of Medical Sciences, Gonabad, Iran. Gonabad University of Medical Sciences