en Original Article <p style="text-align: justify;"><span style="font-size: 14px;"><span style="font-family: times new roman;"><strong>Background:</strong> Pregnancy and labor is a natural process in human life which may be accompanied with challenges. Postpartum depression (PPD) is a common type of depression. Thus, the present study was conducted to determine the frequency of PPD and its possible risk factors in mothers referred to health centers in Rafsanjan, Iran, in 2015.</span></span></p> <p style="text-align: justify;"><span style="font-size: 14px;"><span style="font-family: times new roman;"><strong>Materials and Methods:</strong> The present descriptive study was performed on 250 women who had given birth in the previous 2-6 months and had referred to health centers in Rafsanjan for various care services in 2015. The subjects were randomly selected and entered into the study. The data collection tools consisted of the Edinburgh Postnatal Depression Scale (EPDS) and a demographic characteristics checklist. The collected data were analyzed using chi-square test, t-test, and logistic regression.</span></span></p> <p style="text-align: justify;"><span style="font-size: 14px;"><span style="font-family: times new roman;"><strong>Results:</strong> Among the participants, 129 (68.5%) mothers had PPD. Of the studied factors, unplanned pregnancy could predicted the incidence of PPD (P = 0.004). No difference was observed between mothers with and without PPD in terms of pregnancy order, delivery method, education level, occupation, history of substance abuse, and previous history of depression.&nbsp;</span></span></p> <p style="text-align: justify;"><span style="font-size: 14px;"><span style="font-family: times new roman;"><strong>Conclusions: </strong>The prevalence of PPD in Rafsanjan is high. Unplanned pregnancy had a significant relationship with PPD; thus, the related specialists and authorities must plan and take measures in this regard. </span></span></p> Postpartum Depression,Unplanned Pregnancy,Risk Factors,Pregnancy, 17 24 http://johe.rums.ac.ir/browse.php?a_code=A-10-97-4&slc_lang=en&sid=1 A Manshoori a.manshoori@gmail.com 22400319475328460010445 22400319475328460010445 No Dept of. Obstetrics and Gynecology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Rafsanjan University of Medical Sciences R Bidaki reza-bidaki111@yahoo.com 22400319475328460010446 22400319475328460010446 Yes Research Center of Addiction and Behavioral Sciences, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Shahid Sadoughi University of Medical Sciences H Esmaily hamide.esmaily@yahoo.com 22400319475328460010447 22400319475328460010447 No Rafsanjan University of Medical Sciences, Rafsanjan, Iran Rafsanjan University of Medical Sciences