en Occupational Health Original Article <p style="text-align: justify;"><span style="font-family: times new roman;"><strong>Background: </strong>Every year, eating, exercise, work, and travel patterns change during the holidays and these behavioral changes at a larger scale may cause death due to cardiovascular disease (CVD). Considering the importance of CVD, the present study was conducted for the first time in Iran to determine the differences in the ratio of deaths due to CVD on holidays and working days.</span></p> <p style="text-align: justify;"><span style="font-family: times new roman;"><strong>Materials and Methods:</strong> This was a descriptive study. The study population consisted of all hospitalized cases of CVD in the city of Rafsanjan, Iran, during the years 2010-2014. Data on individuals were collected through electronic systems available at Ali-ibn Abi Talib Hospital, Rafsanjan. Holidays were specified using the official Iranian calendar and the number of deaths caused by CVD on holidays and working days were extracted. Finally, the collected data were entered into SPSS software and were analyzed using independent t-test, chi-square, and logistic regression model.</span></p> <p style="text-align: justify;"><span style="font-family: times new roman;"><strong>Results:</strong> Within 5 years, about 11124 cases of hospitalizations due to CVD were studied. Among the total hospitalized cases, 993 deaths were reported. Of these cases of death 3.5% occurred on Iranian New Year holidays, 4.5% on Islamic and National holidays, 11.5% on Fridays and 80.5% on the ordinary days of the year (P< 0.001). The results of logistic regression model have revealed that after considering the effects of other variables the odds ratio of death due to CVD was 1.913, 1.477 and 1.572 respectively in Iranian New Year holidays, Islamic and National holidays and Fridays compared with the ordinary days of the year.</span></p> <p style="text-align: justify;"><span style="font-family: times new roman;"><strong>Conclusions:</strong> The results of this study showed that the holidays in Iran may have an additive effect in relation to deaths from cardiovascular disease.</span></p> Hospital, Cardiovascular Diseases, Holidays, Iran 182 189 http://johe.rums.ac.ir/browse.php?a_code=A-10-41-4&slc_lang=en&sid=1 A Shokufamanesh 22400319475328460011706 22400319475328460011706 No Dept. of Epidemiology and Biostatistics, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences R Vazirinejad 22400319475328460011707 22400319475328460011707 No PhD of Epidemiology, Social Determinants of Health Research Centre, Medical School, Rafsanjan University of Medical Science, Rafsanjan, Iran Rafsanjan University of Medical Sciences M Mirzaei 22400319475328460011708 22400319475328460011708 No Cardiologist, Dept. of Internal Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences H Ahmadinia 22400319475328460011709 22400319475328460011709 No Dept. of Biostatistics, Hamadan University of Medical Sciences, Hamadan, Iran. Rafsanjan University of Medical Sciences M Rezaeian moeygmr2@yahoo.co.uk 22400319475328460011710 22400319475328460011710 Yes Dept. of Epidemiology and Biostatistics, Occupational Environmental Research Center, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences