en Epidemiology Original Article <div style="text-align: justify;"><span style="font-family:arial;"><strong>Background:</strong> Head and neck cancer is the sixth most common cancer in the world, with 690,000 new cases identified in 2012. There are some arguments over an increase or a decrease in the incidence rate of head and neck cancers in different locations. This study is conducted aimed at determining the frequency of head and neck cancers in patients referring to Rafsanjan Ali-ibn&nbsp;Abi Talib hospital pathology lab from 2005 to 2016 and comparing frequencies in different years.<br> <strong>Materials and Methods: </strong>In this descriptive study, a datasheet was prepared from medical files from 2005 to 2016, containing the date, age, sex, type, and site of tumors in patients admitted to Ali-ibn&nbsp;Abi Talib hospital pathology lab, Rafsanjan, Iran. Data were analyzed using chi-square or Fisher&rsquo;s exact tests.&nbsp;<br> <strong>Results: </strong>In this study, 343 cancer cases were obtained from 27414 files (1.25%). Out of these cases, 33.2% (114 cases) and 66.8% (229 cases) occurred in women and men (P < 0.001), respectively. The most common site of the tumor was skin, and the most common cancer was basal cell carcinoma. There was no evidence of a significant linear trend for the incidence of malignancies from March 21, 2005 to September 22, 2015.<br> <strong>Conclusions: </strong>The present study did not show any significant changes in the frequency of head and neck cancers in different years. We need to study the incidence rates of more prevalent risk factors, such as tobacco and alcohol in these patients simultaneously.</span><br> &nbsp;</div> Head and Neck,Cancer,Incidence,Epidemiology,Frequency, 1 5 http://johe.rums.ac.ir/browse.php?a_code=A-10-256-1&slc_lang=en&sid=1 Ateke Movaghari ateke.movaghari@gmail.com 22400319475328460010845 22400319475328460010845 No Department of Oral Medicine, Dental School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences Morteza Khademalhosseini Mortezakhademalhosseini@gmail.com 22400319475328460010846 22400319475328460010846 Yes Department of Pathology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences Nazanin Jalali nazaninejalali@gmail.com 22400319475328460010847 22400319475328460010847 No Department of Neurology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences Seyed Hossein Yazdi Mirmokhalesouni 22400319475328460010848 22400319475328460010848 No Dental School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences Mahmood Sheikh Fathollahi mamoosh502002@yahoo.com 22400319475328460010849 22400319475328460010849 No Department of Epidemiology and Biostatistics, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences