en Epidemiology Case Report <p style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Arial;"><strong>Background:</strong> COVID-19 is a viral infection that causes pneumonia with dyspnea, cough, and fever. Its outcomes are more severe in patients with diabetes, hypertension, and other disorders than in healthy people. New-onset diabetes and diabetic ketoacidosis (DKA) have been reported as the complications of COVID-19 in several studies. It seems that the prevalence of DKA due to Covid-19 is increasing. Therefore, two cases of individuals with DKA due to COVID-19 are presented in this study to inform other researchers about the details of this phenomenon.<br> <strong>Material and Methods:</strong> Demographic characteristics, medical histories, physical examinations, laboratory investigations, real-time RT-PCR tests, computed tomography (CT) imaging studies, given treatments, clinical courses, and management outcomes were documented prospectively. <span dir="RTL"></span><br> <strong>Results</strong>: In the present experience, the manifestation of COVID-19 disease in the second case with a history of diabetes was more severe than in the first case. In the second case, with underlying diabetes and COVID-19, the DKA manifestation was associated with consciousness loss, severe restlessness, and respiratory distress; however, in the first case, with COVID-19 without diabetes, the DKA manifestation was associated with anorexia, weight loss, and lack of respiratory distress, which were milder symptoms than the second case.<br> <strong>Conclusion:</strong> Due to the high prevalence of diabetes mellitus and COVID-19 in Iran, it is recommended to raise awareness of DKA symptoms among health professionals.</span></span></p> Diabetes Complications,Diabetic Ketoacidosis,Covid-19, 12 16 http://johe.rums.ac.ir/browse.php?a_code=A-10-386-1&slc_lang=en&sid=1 Mehdi Kafi mmm.kafi@yahoo.com 22400319475328460011114 22400319475328460011114 No Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Science Maryam Karimifard karimifardmaryam6@gmail.com 22400319475328460011115 22400319475328460011115 Yes Assistant Prof., Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Science Sima Amiorroaya s.aminorroaya@shu.ac.uk 22400319475328460011116 22400319475328460011116 No Associate Prof., Dept. of Engineering and Mathematics, Sheffield Hallam University, Sheffield S1 1WB, UK. Sheffield Hallam University