en Occupational Health Original Article <p style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Arial;"><a name="OLE_LINK26"></a><a name="OLE_LINK25"><strong>Background:</strong></a> The present study aims to assess the prevalence of musculoskeletal disorders and occupational stress among workers of a factory in Iran during the COVID-19 pandemic.<br> <strong>Materials and Methods</strong>: This cross-sectional study was conducted on all workers of an engineering company (140 participants). The tools used in the present study included the Perceived Stress Scale (PSS-14) Questionnaire and the Body Map Questionnaire. The participants were asked to respond to the questions according to their physical and mental status after the onset of the COVID-19 pandemic. The data were analyzed using SPSS V25.0.<br> <strong>Results</strong>: The most frequently reported musculoskeletal issues were related to the back (61.4%) and neck (53.6%) areas, while the lowest prevalence was related to elbows (17.9%). A significant correlation was found between the final scores obtained from the PSS-14 and Body Map Questionnaires for the neck (P = 0.026) and shoulder (P = 0.009) areas. Besides, a significant correlation was found between the participants&#39; gender and pain in the neck (P = 0.005) and shoulder (P = 0.048) areas. Furthermore, a significant correlation was found between marital status and pain in the pelvis (P = 0.034) and leg (P = 0.007) areas as well as the thigh and knee (P = 0.017) areas.<br> <strong>Conclusions</strong>: The COVID-19 pandemic has affected various aspects of mental and physical health in occupational environments and has contributed to an increase in musculoskeletal pain and occupational stress levels. Thus, the adoption of effective strategies and the use of a comprehensive stress management program are suggested to prevent musculoskeletal disorders in occupational environments.</span></span></p> COVID-19,Occupational Stress,Musculoskeletal Disorders,Occupational Health. 183 192 http://johe.rums.ac.ir/browse.php?a_code=A-10-412-1&slc_lang=en&sid=1 Elham Akhlaghi Pirposhteh 22400319475328460011861 22400319475328460011861 No PhD Student in Occupational Health Engineering, Dept. of Occupational Health Engineering, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Niloofar Sheibani niloofarsheibani94@gmail.com 22400319475328460011862 22400319475328460011862 No MSc in Ergonomics, Dept. of Occupational Health, School of Health, Tehran University of Medical Sciences, Tehran, Iran. Tehran University of Medical Sciences Atefeh Beheshti 22400319475328460011863 22400319475328460011863 No BSc in Occupational Health Engineering, Dept. of Occupational Health and Safety at Work Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Nader Bakhshi 22400319475328460011864 22400319475328460011864 No MSc in Environmental Management (HSE), Dept. of Environmental Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran. Ali Salehi Sahl Abadi asalehi529@gmail.com 22400319475328460011865 22400319475328460011865 Yes Assistant Prof., Workplace Health Promotion Research Center, Dept. of Occupational Health and Safety at Work, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.