en Occupational Health Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:250%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:250%"><span arial="" style="font-family:"><span style="color:black">Background:</span></span></span></span></b><span style="font-size:9.0pt"><span style="line-height:250%"><span arial="" style="font-family:"><span style="color:black"> Nursing is a profession through which a set of sometimes difficult tasks is assigned to nurses who face several physical and mental stressors in the workplace. Therefore, this study investigates the nurses&#39; quality of life level in Khorramabad (Iran) during the first 3 months of the COVID-19 epidemic.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:250%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:250%"><span arial="" style="font-family:"><span style="color:black">Materials and Methods: </span></span></span></span></b><span style="font-size:9.0pt"><span style="line-height:250%"><span arial="" style="font-family:"><span style="color:black">This descriptive study was carried out on 361 nurses of Khorramabad teaching hospitals in the first 3 months of the COVID-19 epidemic in 2020. Participants were selected by stratified random sampling of the nursing population. Data were collected using the World Health Organization Quality of Life (WHOQOL-BREF) questionnaire. The independent t-test and ANOVA were used to analyze the data. SPSS&nbsp;version&nbsp;22&nbsp;was used for data analysis, and P-value &le; 0.05 was considered statistically significant.</span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:250%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:250%"><span arial="" style="font-family:"><span style="color:black">Results: </span></span></span></span></b><span style="font-size:9.0pt"><span style="line-height:250%"><span arial="" style="font-family:"><span style="color:black">There was a significant association between marital status, having children, spouse employment status, hospital ward, and quality of life of nurses over the time of the COVID-19 outbreak (P <0.05). No significant association was observed between age, gender, education level, work experience, having a second job, and level of quality of life in nurses over the COVID-19 outbreak.&nbsp; </span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:250%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:250%"><span arial="" style="font-family:"><span style="color:black">Conclusions:</span></span></span></span></b><span style="font-size:9.0pt"><span style="line-height:250%"><span arial="" style="font-family:"><span style="color:black"> Most nurses had a good quality of life; however, the quality of life varied depending on marital status, number of children, spouse employment status, and place of employment in nurses.</span></span></span></span></span></span></span></div> Quality of Life,Nurses,COVID-19 Virus, 121 128 http://johe.rums.ac.ir/browse.php?a_code=A-10-434-2&slc_lang=en&sid=1 Rajab Rashidi rashidi.r270@gmail.com 5929542589 22400319475328460011299 Yes Associate Prof., Dept. of Occupational Health, Nutrition Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran. Lorestan University of Medical Sciences Khatereh Anbari dr.anbari@gmail.com 22400319475328460011300 22400319475328460011300 No Associate Prof., Social Determinants of Health Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. Lorestan University of Medical Sciences Rasool Mohammadi rasool.mehr2002@gmail.com 22400319475328460011301 22400319475328460011301 No Assistant Prof., Nutrition Health Research Center, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran. Lorestan University of Medical Sciences