en Occupational Health Original Article <div style="text-align: justify;"><span style="font-size:10pt"><span style="line-height:150%"><span courier="" new="" style="font-family:"><span style="color:black"><b><span style="font-size:11.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Background: </span></span></span></b><span style="font-size:11.0pt"><span style="line-height:150%"><span arial="" style="font-family:">There are considerable opium addicts, particularly among workers in Iran&#39;s industrial sectors. This study aimed to investigate the effects of simultaneous exposure to excessive noise and opium addiction on adult rat sperm parameters.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span courier="" new="" style="font-family:"><span style="color:black"><b><span style="font-size:11.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Materials and Methods:</span></span></span></b><span style="font-size:11.0pt"><span style="line-height:150%"><span arial="" style="font-family:"> In this experimental study 42 adult Wistar male rats in 6 groups were studied as follows: group 1 control, group 2 exposed to noise (100 dB) 8 h/day, group 3 received daily 50 mg/case opium solution, group 4 received daily 100 mg/case opium solution, group 5 received daily 50 mg/case opium solution and exposed to noise 8h/day, and group 6 received daily 100 mg/case opium solution and exposed to noise 8h/day. After 50 days, cauda epididymis was removed for sperm parameters examination (WHO guidelines).</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span courier="" new="" style="font-family:"><span style="color:black"><b><span style="font-size:11.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Results:</span></span></span></b><span style="font-size:11.0pt"><span style="line-height:150%"><span arial="" style="font-family:"> In the groups receiving opium (50 and 100 mg/case), sperm count, sperm viability, and normal sperm morphology (%) significantly decreased compared to the control group. Exposure to noise and consumption of opium solution simultaneously significantly reduced the count, viability, and percentage of sperm with normal morphology in both selected doses, as well as a significant difference between groups 5 and 6 in count, viability, and normal sperm morphology(%) parameters(P<0.05). </span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:150%"><span courier="" new="" style="font-family:"><span style="color:black"><b><span style="font-size:11.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Conclusions:</span></span></span></b><span style="font-size:11.0pt"><span style="line-height:150%"><span arial="" style="font-family:"> According to the results, noise exposure and taking opium would actively reduce the count, viability, and normal sperm morphology. It is therefore suggested that the mechanism of such effects should be investigated in animal and human studies.</span></span></span></span></span></span></span></div> Sperm,Noise,Opium,Addiction, 90 97 http://johe.rums.ac.ir/browse.php?a_code=A-10-35-6&slc_lang=en&sid=1 Ali Tajpoor alitajpoor92@gmail.com 22400319475328460010759 22400319475328460010759 No M.Sc in Occupational Health Engineering, Dept. of Occupational Health Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Tarbiat Modares University Farshad Nadri nadrifarshad64@gmail.com 22400319475328460010760 22400319475328460010760 Yes Assisstant Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Kermanshah Medical Sciences University Ali Khavanin * khavanin@modares.ac.ir 22400319475328460010761 22400319475328460010761 No Professor in Occupational Health Engineering, Dept. of Occupational Health Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Tarbiat Modares University Shahram Vosooghi sh_vosoughi@yahoo.com 22400319475328460010762 22400319475328460010762 No Associate Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Iran University of Medical Sciences, Tehran, Iran. Iran Medical Sciences University Hamed Nadri nadrihamed@gmail.com 22400319475328460010763 22400319475328460010763 No Assisstant Prof., in Occupational Health, Dept. of Occupational Health Engineering, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran. Shoushtar Faculty of Medical Sciences University Sajad Zare s.zare64@gmail.com 22400319475328460010764 22400319475328460010764 No Associate Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Kerman University of Medical Sciences, Kerman, Iran. Kerman Medical Sciences University