en Epidemiology Original Article <div style="text-align: justify;"><span style="font-family:Arial;"><span style="font-size:10pt"><span style="line-height:200%"><span style="color:black"><b>Background: </b>Cancer and underlying diseases in the covid-19 pandemic created more problems for those affected by the <span dir="RTL" lang="AR-SA">coronavirus</span>. This study aimed to evaluat patients&#39; mortality and related factors based on underlying diseases in people with COVID-19.</span></span></span><br> <span style="font-size:10pt"><span style="line-height:200%"><span style="color:black"><b>Materials and Methods:</b> This descriptive study was performed on patients with COVID-19 admitted to Kermanshah hospital from February 22, 2020<span dir="RTL" lang="FA">,</span> to September 22, 2021. Clinical information was obtained from medical records and patient&#39;s history was <a name="_Hlk120888795">extracted from the case documentation. The mortality and case fatality rates</a> in hospitalized COVID-19 cases were calculated. Analysis of logistic regression models was used to identify prognostic factors of death.<span lang="FA" dir="RTL" style="font-family:"Arial","sans-serif""></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:200%"><span style="color:black"><b>Results:</b> Out of 55813 patients admitted to the hospital due to covid-19 on the mentioned date, 4260 died. Furthermore, the most common underlying disease in hospitalized patients due to covid 19 was hypertension (11.4%)<span dir="RTL" lang="FA">.</span> The prevalence of cancers was 1.4%. The highest in-hospital case fatality rate was chronic kidney disease (CKD) (21.3%) and cancer (16.6%). In addition, among the underlying diseases, the odds ratio of CKD was 2.12 (CI90%= 1.38- 3.26), and cancers were 2.06 (CI95%= 1.25- 3.37), the most important underlying diseases for odds of death.<span lang="FA" dir="RTL" style="font-family:"Arial","sans-serif""></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:200%"><span style="color:black"><b>Conclusion:</b> The prevalence of hypertension (HTN) and cardiovascular diseases (CVD) was higher in hospitalized patients with COVID-19 than patients with other underlying diseases. However, patients with CKD and cancer had a higher odds ratio for death. Therefore, attention to managing patients with CKD and cancers should be seriously considered and followed.<span lang="FA" dir="RTL" style="font-family:"Arial","sans-serif""></span></span></span></span></span><br> &nbsp;</div> COVID -19,Preexisting Diseases,Iran, 4 11 http://johe.rums.ac.ir/browse.php?a_code=A-10-543-1&slc_lang=en&sid=1 Leila Rezakhani leila_rezakhani@yahoo.com 22400319475328460010782 22400319475328460010782 Yes Assistant Prof., Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Dept. of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Kermanshah University of Medical Sciences Mozafar Khazaei 22400319475328460010783 22400319475328460010783 No Professor, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Dept. of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Kermanshah University of Medical Sciences, Siavash Vaziri 22400319475328460010784 22400319475328460010784 No Professor, Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Kermanshah University of Medical Sciences Fatemeh Khosravi Shadmani 22400319475328460010785 22400319475328460010785 No Assistant Prof., Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Kermanshah University of Medical Sciences