en Occupational Health Review Article <div style="text-align: justify;"><span style="font-family:Arial;"><span style="font-size:10pt"><span style="line-height:200%"><span style="color:black"><b>Background: </b>Infertility is a major problem around the world. The male partner is responsible for half of the infertility. Several factors can affect the male reproductive system and create infertility. Occupational exposure is one of the main factors in male infertility. Present study aimed to review the literature on chemical occupational exposure effects on male fertility<span dir="RTL" lang="AR-SA">.</span><span style="font-family:"Arial","sans-serif""></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:200%"><span style="color:black"><b>Materials and Methods:</b> For this narrative review online search was conducted on scientific databases including PubMed, Scopus, and Web of Sciences by the following keywords: male fertility/infertility, sperm, occupational, chemical agents, work environment, pesticides painters, farmers, and farmworkers. In this study, we categorized sperm characteristics (quality, count, mobility, morphology, and viability) and reviewed studies (between 1985 &ndash; 2022) that assessed chemical occupational effects separately (chemical industries, farmers, and painters) on sperm characteristics. We tried to review the most recently reported studies in this issue and categorized them into subgroups for easy understanding.</span></span></span><br> <span style="font-size:10pt"><span style="line-height:200%"><span style="color:black"><b>Result:</b>&nbsp; Most studies reported a positive association between chemical exposure and defects in sperm parameters. Existing research suggests that the association between industrial life and infertility development is probably reciprocal.</span></span></span><br> <span style="font-size:10pt"><span style="line-height:200%"><span style="color:black"><b>Conclusion:</b>&nbsp; Results of the studies are controversial, and it seems epidemiological investigations cannot approve the harmful effects of some occupational chemical exposure on fertility potential and sperm parameters. During interpreting the results of the studies, it is important to emphasize that the type of chemical mixtures, duration of exposure (chronic exposure to different levels), and number of compounds, physiological and psychological conditions can play a key role. <span style="font-family:"Arial","sans-serif""></span></span></span></span></span><br> &nbsp;</div> Occupation,chemical,Sperm,Infertility,farmer,pesticide,painter, 50 58 http://johe.rums.ac.ir/browse.php?a_code=A-10-511-1&slc_lang=en&sid=1 Soheila Pourmasumi Spourmasumi@yahoo.com 22400319475328460010810 22400319475328460010810 No Assistant Prof. in Reproductive Medicine, Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences Reza Vazirinejad rvazirinejad@yahoo.co.uk 22400319475328460010811 22400319475328460010811 No Professor in Epidemiology, Dept. of Community Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences Zahra Ahmadi leila5823@yahoo.com 22400319475328460010812 22400319475328460010812 No M.Sc in Nutrition, Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences Ali Mehdipour 22400319475328460010813 22400319475328460010813 No Assistant Prof. in Medical Physics, Dept. of Radiology, School of Allied Medical Sciences, Rafsanjan University of Medical Sciences, Rafsnajan, Iran. Rafsanjan University of Medical Sciences Alireza Nazari drnazari57@gmail.com 22400319475328460010814 22400319475328460010814 Yes Associate Prof. in Urology, Dept. of Surgery, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Rafsanjan University of Medical Sciences