Journal of Occupational Health and Epidemiology
J Occup Health Epidemiol
Medical Sciences
http://johe.rums.ac.ir
224
admin
2251-8096
2252-0902
10.61186/johe
0
en
jalali
1400
1
1
gregorian
2021
4
1
10
2
online
1
fulltext
en
A Contact Tracing Prospective Cohort Retrieving Epidemiological Facts on SARS-CoV-2 Transmission Aspects: A Serological Analysis in an Iranian Community
Epidemiology
Original Article
<p style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Arial;"><a name="OLE_LINK25"><strong>Background: </strong></a>The spread of the novel coronavirus seems mysterious enough to make us double-check the indices being used to predict its transmission. In this study, <a name="_Hlk64673302">serological analysis was performed to assess some metric and epidemiological aspects of the infection and its transmissibility among people in contact with SARA-CoV-2 patients. </a><br>
<strong>Material and Methods:</strong> A total of 453 contacts of 40 COVID-19 patients entered this contact tracing prospective cohort study. Accordingly, SARS-CoV-2 patients were diagnosed by the real-time polymerase chain reaction testing of nasopharyngeal samples. The infectiousness history was detected by the serological testing of IgG and IgM. Trained expert team completed two questionnaires, and blood samples were taken by experts in a laboratory. Data were analyzed using SPSS V21.0 and R software.<br>
<strong>Results:</strong> <a name="_Hlk49554375">The mean ages of the SARS-CoV-2 patients and the contacts were 53.0±18.2 and 30.8±19.3 years, respectively. The overall R<sub>0</sub> of the infection was 2.58. Household and non-household secondary attack rates (SAR) were 20% (95%CI; 12.7–27.3) and 11.3% (95%CI; 6.1-16.5), respectively. The transmission probability of each contact was 0.0205, and the serial interval was 6.4±4.6 (95% CI; 5.2–7.6) days. The SAR was higher among the contacts who were exposed to asymptomatic primary cases (28%, 95%CI; 10-46%) than (13.8%, 95%CI; 9.4-18.2) among those exposed to symptomatic patients. </a><br>
<strong>Conclusions:</strong> It is concluded that the herd immunity of 60 to 65% is needed in human communities, based on the amount of R<sub>0</sub> estimated in our survey. The findings demonstrated the amount of the reduction in infection <a name="_Hlk84712706">R<sub>0</sub></a>, which is predicted based on both clinical and public health interventions.</span></span></p>
SARS-CoV-2,Serology,Transmission,Iran,
75
85
http://johe.rums.ac.ir/browse.php?a_code=A-10-161-1&slc_lang=en&sid=1
Reza
Vazirinejad
rvazirinejad@yahoo.co.uk
2240031947532846006864
2240031947532846006864
No
Professor, Dept. of Epidemiology, School of Public Health, Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Parvin
Khalili
parvinkhalili61@yahoo.com
2240031947532846006865
2240031947532846006865
Yes
Assistant Prof., Dept. of Epidemiology, School of Public Health, Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Abdollah
Jafarzadeh
jafarzadeh14@yahoo.com
2240031947532846006866
2240031947532846006866
No
Professor, Dept. of Immunology, Kerman University of Medical Sciences, Kerman, Iran.
Kerman University of Medical Sciences
Ziba
Shabani
shabaniz20@yahoo.com
2240031947532846006867
2240031947532846006867
No
Assistant Prof., Dept. of Infection Diseases, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Ahmad
Jamalizadeh
ajamali4749@gmail.com
2240031947532846006868
2240031947532846006868
No
General Physician, Health System Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Batool
Rezaei
rezaie_55@yahoo.com
2240031947532846006869
2240031947532846006869
No
BSc in Midwifery, Health System Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Hassan
Ahmadnia
h.ahmadinia@gmail.com
2240031947532846006870
2240031947532846006870
No
Assistant Prof., Dept. of Epidemiology and Biostatistics, School of Public Health, Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Mohammad-taghi
Rezayati
m.t.rezayati@gmail.com
2240031947532846006871
2240031947532846006871
No
BSc in Laboratory Sciences, Dept. of Immunology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Mohammad
Ebrahimian
m.ebi51@yahoo.com
2240031947532846006872
2240031947532846006872
No
BSc in Laboratory Sciences, Pathobiological Laboratory, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Gholamreza
Mehralinasab
gh.mehrali@gmail.com
2240031947532846006873
2240031947532846006873
No
BSc in Disease Control, Health System Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences
Azam
Bagherizadeh
azambagherizadeh@yahoo.com
2240031947532846006874
2240031947532846006874
No
BSc in Laboratory Sciences, Pathobiological Laboratory, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences
Shima
Bazaz
bazzaz6599@gmail.com
2240031947532846006875
2240031947532846006875
No
BSc in Laboratory Sciences, Pathobiological Laboratory, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences, Rafsanjan
Erfan
Vazirinejad
erfanvazirinejad1@gmail.com
2240031947532846006876
2240031947532846006876
No
Medical Student, Medical School, University of Pecs Medical School, Pecs, Hungary.
University of Pecs Medical School