Journal of Occupational Health and Epidemiology
J Occup Health Epidemiol
Medical Sciences
http://johe.rums.ac.ir
224
admin
2251-8096
2252-0902
10.61186/johe
0
en
jalali
1391
7
1
gregorian
2012
10
1
1
3
online
1
fulltext
en
Lower immunity to tetanus in cigarette smoker subjects
Original Article
<p> <strong> Background: </strong>Cigarette smoking has been linked with the suppression of immune responses and increased susceptibility to numerous infections in humans. Tetanus is also a major public health problem in many countries. The aim of the present study was to evaluate the serum levels of anti-tetanus toxin antibodies in c igarette smoking and healthy non-smoking people .</p>
<p> <strong> Materials and Methods: </strong>A total of 100 c igarette smokers and 100 age-matched healthy non-smoker individuals were enrolled in this descriptive study. A blood sample was collected from each participant. The samples were tested for the levels of anti-tetanus toxin antibodies b y use of enzyme linked immunosorbent assay.</p>
<p> <strong> Results: </strong>The seroprotective rate of anti-tetanus toxin antibodies in non-smoking group (99%) was significantly higher than that observed in c igarette smoking group (78%, P<0.0001). The mean titer of anti-tetanus toxin antibodies in non-smoking group ( 5.32± 0.26 IU/ml) was also significantly higher than that in smoker subjects ( 1.03 ± 0.16 IU/ml P<0.0001). The mean titer of anti-tetanus toxin antibodies in individuals with smoking duration >10 years was significantly lower than that among smokers with smoking duration ≤10 years (0.59 ± 0.12 IU/ml vs 1.98 ± 0.41 IU/ml P<0.001). The seroprotection rate was also significantly lower in persons with smoking duration >10 years in comparison to smokers with smoking duration ≤10 years (72.1% vs 90.6% P=0.037). The mean titer of anti-tetanus toxin antibodies in individuals with daily smoking >10 cigarettes was also significantly lower in comparison to smokers with daily smoking ≤10 cigarettes (0.68 ± 0.15 IU/ml vs 1.63 ± 0.36 IU/ml P<0.001).</p>
<p> <strong> Conclusion: </strong>These results showed lower levels of anti-tetanus toxin antibodies in cigarette smokers which represents c igarette smoking as a risk factor for susceptibility to tetanus. A negative association was also observed between the immunity to tetanus and smoking burden.</p>
Immunity, Tetanus, Antibody, Cigar Smoking
124
131
http://johe.rums.ac.ir/browse.php?a_code=A-10-61-1&slc_lang=en&sid=1
A
Jafarzadeh
Jafarzadeh14@yahoo.com
2240031947532846004289
2240031947532846004289
No
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences
Z
Shabani
shabaniz20@yahoo.com
2240031947532846004290
2240031947532846004290
Yes
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences
M
Hassanabadi
moa.Hassanabadi@gmail.com
2240031947532846004291
2240031947532846004291
No
Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences
MT
Rezayati
m.rezayati@yahoo.com
2240031947532846004292
2240031947532846004292
No
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences
M
Nemati
nemati_m22@yahoo.com
2240031947532846004293
2240031947532846004293
No
Dept. of Microbiology and Immunology, Medical of School, Kerman University of Medical Sciences, Kerman, Iran.
Kerman University of Medical Sciences
AR
Sayadi
sayadiahmad@yahoo.com
2240031947532846004294
2240031947532846004294
No
Faculty Member, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences
A
Sheikhi
Sheikhi
2240031947532846004295
2240031947532846004295
No
Dept. of Immunology, Medical of School, Dezful University of Medical Sciences, Dezful, Iran.
Dezful University of Medical Sciences
R
Vazirinejad
rvazirinejad@yahoo.co.uk
2240031947532846004296
2240031947532846004296
No
Professor, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Rafsanjan University of Medical Sciences