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K Zare, Hr Adeli, N Naeimi, A Naghizadeh,
Volume 3, Issue 1 (1-2014)
Abstract

Background: Morpholine is a toxic substance used in industry and agriculture and can be absorbed into the body through ingestion, inhalation, and the skin. The present study aimed to assess the effect of morpholine and physiological serum ingestion on qualitative and quantitative characteristics of white blood cells and kidney tissue of white male mice.

Materials and Methods: In the present study, 40 adult NMRI male Albino mice were placed in 4 groups control group, physiological serum (sham) group, treatment group A [fed with 300 mg/kg of 1 ml of the prepared solution (0.009 ml morpholine + 0.091 ml of distilled water) per day for 15 days], and group B (the same volume of morpholine and physiological serum). After weighing, anesthesia, and blood sampling, all considered parameters were measured using MOTIC software. In addition, macroscopic and microscopic studies were conducted on prepared slides and obtained data were analyzed using SPSS software.

Results: In group A, reduced thickness of the outer cortex of the kidney (proximal convoluted tubule), increased thickness of the inner cortex (Malpighian body’s, distal convoluted tubule), and reduced external medulla (Henle’s loop) were significant compared to the control group and sham group. However, no significant difference was found among the groups with regard to the internal medulla (collecting pipes). Moreover, the kidney gained weight compared to the whole body. Changes in white blood cells in group A were significant compared to group B.

Conclusions: Stress morpholine causes changes in blood parameters, increased filtration, decreased reabsorption and absorption, weight loss, inflammation, hyperemia, urinary tract reconstruction and resulted polyuria. However, these impacts reduced via physiological serum.


Vida Rezaei-Hachesu, Shadi Naderyan Fe'li, Rajabali Hokmabadi, Meghdad Kazemi, Farideh Golbabaei,
Volume 11, Issue 2 (4-2022)
Abstract

Background: There is evidence that exposure to heat stress over time may lead to chronic kidney disease. This study aimed to summarize the evidence on the effects of heat stress on renal function among individuals exposed to occupational heat stress.
Materials and Methods: In this systematic review, all papers on the effect of heat stress on kidney function among workers at any workplace and heat level were included. Reviews, case reports, conference proceedings, letters, editorials, abstracts without full text, in-vitro, and animal studies were excluded. Furthermore, studies conducted on children, general populations, and hospitalized patients, as well as those not measuring heat stress, were also excluded. Medline, Scopus, ISI, and Embase databases were searched from 1st January 1991 to 19th October 2021. Search criteria were prepared by combining an 'exposed population' AND 'exposure' AND 'outcome' keywords. Quality assessment was done using the National Institutes of Health Quality Assessment tool.
Results: A total of 24 articles with 14,282 participants were considered for qualitative synthesis. Although most papers indicated a positive association between heat stress and kidney dysfunction, especially regarding dehydration, the present study found heterogeneous evidence. Glomerular filtration rate, serum creatinine level, and albumin-to-creatinine ratio, due to occupational heat stress, were other markers mentioned in primary studies.
Conclusions: This review highlighted the impact of occupational heat stress on renal function. Among the markers investigated in this review, most studies reported a positive association between occupational heat stress and dehydration.
 

 


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