Volume 10, Issue 2 (Spring 2021)                   JOHE 2021, 10(2): 75-85 | Back to browse issues page

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Vazirinejad R, Khalili P, Jafarzadeh A, Shabani Z, Jamalizadeh A, Rezaei B, et al . A Contact Tracing Prospective Cohort Retrieving Epidemiological Facts on SARS-CoV-2 Transmission Aspects: A Serological Analysis in an Iranian Community. JOHE. 2021; 10 (2) :75-85
URL: http://johe.rums.ac.ir/article-1-469-en.html
1- Professor, Dept. of Epidemiology, School of Public Health, Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Assistant Prof., Dept. of Epidemiology, School of Public Health, Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , parvinkhalili61@yahoo.com
3- Professor, Dept. of Immunology, Kerman University of Medical Sciences, Kerman, Iran.
4- Assistant Prof., Dept. of Infection Diseases, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- General Physician, Health System Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
6- BSc in Midwifery, Health System Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
7- Assistant Prof., Dept. of Epidemiology and Biostatistics, School of Public Health, Social Determinants of Health Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
8- BSc in Laboratory Sciences, Dept. of Immunology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
9- BSc in Laboratory Sciences, Pathobiological Laboratory, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
10- BSc in Disease Control, Health System Research Centre, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
11- Medical Student, Medical School, University of Pecs Medical School, Pecs, Hungary.
Abstract:   (121 Views)

Background: The spread of the novel coronavirus seems mysterious enough to make us double-check the indices being used to predict its transmission. In this study, serological analysis was performed to assess some metric and epidemiological aspects of the infection and its transmissibility among people in contact with SARA-CoV-2 patients.   
Material and Methods: A total of 453 contacts of 40 COVID-19 patients entered this contact tracing prospective cohort study. Accordingly, SARS-CoV-2 patients were diagnosed by the real-time polymerase chain reaction testing of nasopharyngeal samples. The infectiousness history was detected by the serological testing of IgG and IgM. Trained expert team completed two questionnaires, and blood samples were taken by experts in a laboratory. Data were analyzed using SPSS V21.0 and R software.
Results: The mean ages of the SARS-CoV-2 patients and the contacts were 53.0±18.2 and 30.8±19.3 years, respectively. The overall R0 of the infection was 2.58. Household and non-household secondary attack rates (SAR) were 20% (95%CI; 12.7–27.3) and 11.3% (95%CI; 6.1-16.5), respectively. The transmission probability of each contact was 0.0205, and the serial interval was 6.4±4.6 (95% CI; 5.2–7.6) days. The SAR was higher among the contacts who were exposed to asymptomatic primary cases (28%, 95%CI; 10-46%) than (13.8%, 95%CI; 9.4-18.2) among those exposed to symptomatic patients. 
Conclusions: It is concluded that the herd immunity of 60 to 65% is needed in human communities, based on the amount of R0 estimated in our survey. The findings demonstrated the amount of the reduction in infection R0, which is predicted based on both clinical and public health interventions.

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Type of Study: Original Article | Subject: Epidemiology
Received: 2021/09/9 | Accepted: 2021/10/28 | ePublished: 2021/10/30

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