Volume 11, Issue 3 (Summer 2022)                   J Occup Health Epidemiol 2022, 11(3): 171-179 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Heydari Z, Ansari Jaberi A, Seyed Bagheri S H, Negahban Bonabi T. Effects of Rosemary Oil on Osteoarthritis Symptoms in the Elderly: A Double‌-Blind Randomized Control. J Occup Health Epidemiol 2022; 11 (3) :171-179
URL: http://johe.rums.ac.ir/article-1-544-en.html

Related article in
Google Scholar

1- M.Sc Student in Geriateric Nursing, School of Nursing and Midwifery, Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Instructor, Dept. of Psychiatric and Mental Health Nursing, Social Determinants of Health Research Center, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3- Assistant Prof., Dept, of Neonatal and Pediatric Nursing, School of Nursing and Midwiferry, Non-Communicable, Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- Assistant Prof., Dept. of Community Health Nursing, Social Determinants of Health Research Center, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , negahbant@yahoo.com
Article history
Received: 2022/01/24
Accepted: 2022/07/25
ePublished: 2022/12/17
Subject: Epidemiology
Abstract:   (918 Views)
Background: Despite anti-inflammatory effects of rosemary, there is no broad consensus on the effects of rosemary on osteoarthritis symptoms, being among the most common causes of disability. This study aimed to determine the effects of rosemary ointment on osteoarthritis symptoms in the elderly.
Materials & Methods: In this double-blind randomized trial, 75 elderly patients with knee osteoarthritis were selected from comprehensive health service centers based on inclusion criteria and assigned by the random minimization method to three groups equally. In the intervention and placebo groups, 4 cm of rosemary and Vaseline ointment were applied twice a day, respectively, for 10 days. The control group received no intervention. In addition, the Western Ontario and McMaster Universities Arthritis Index (WOMAC) was measured for the three groups, before, immediately after, and one month after the intervention. Data were analyzed using the Mann Whitney U test, a repeated measures ANOVA, and statistical modeling.
 Results: There were no significant differences among the study groups based on demographic characteristics. In the rosemary and placebo groups, the mean score of the WOMAC and pain improved significantly (p = 0.001) immediately and one month after the intervention. In terms of intergroup comparisons, the WOMAC and pain scores, immediately after the intervention, were significantly higher in the rosemary group than in the other two groups (p < 0.05). However, joint performance and stiffness scores had on significant differences.
Conclusions: The results showed that shortly after the intervention, WOMAC and pain scores improved in the rosemary group. However, no improvement was observed in joint stiffness and function.
Full-Text [PDF 450 kb]   (410 Downloads)    

References
1. Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745-59. [DOI] [PMID]
2. Brandt KD, Radin EL, Dieppe PA, van de Putte L. Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis. 2006;65(10):1261-4. [DOI] [PubMed] [PMCID]
3. Neogi T. The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage. 2013;21(9):1145-53. [DOI] [PubMed] [PMCID]
4. Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A, Arden NK. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014;73(9):1659-64. [DOI] [PMID]
5. Dizaj JY, Soleimanifar M, Hashempour R, Karyani AK, Mohsen F, Zali ME, et al. The burden of musculoskeletal disorders in the countries of the Eastern Mediterranean region of the World Health Organization (EMRO): Study period 2000-2017. [Internet]. 2021. Avaiable from: https://doi.org/10.21203/rs.3.rs-144165/v1 [DOI]
6. Yahaya I, Wright T, Babatunde OO, Cprp N, Helliwell T, Dikomitis L, et al. Prevalence of osteoarthritis in lower middle-and low-income countries: a systematic review and meta-analysis. Rheumatol Int. 2021;41(7):1221-31. [DOI] [PMID] [PMCID]
7. Turkiewicz A, Petersson IF, Björk J, Hawker G, Dahlberg LE, Lohmander LS, et al. Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032. Osteoarthritis Cartilage. 2014;22(11):1826-32. [DOI] [PubMed]
8. Jamshidi A, Kianifard T, Ghorpade R, Shayan M, Mahmoudi M, Chopra A. THU0708 Disparity in osteoarthritis knee prevalence-a tale of two cities in iran (TEHRAN) and india (PUNE): findings from who ilar copcord population survey (STAGE I). Ann Rheum Dis. 2018;77(2):546. [DOI]
9. Conaghan PG, Porcheret M, Kingsbury SR, Gammon A, Soni A, Hurley M, et al. Impact and therapy of osteoarthritis: the Arthritis Care OA Nation 2012 survey. Clin Rheumatol. 2015;34(9):1581-8. [DOI] [PMID]
10. Nishigami T, Tanaka S, Mibu A, Imai R, Wand BM. Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis. Sci Rep. 2021;11(1):5835. [DOI] [PMID] [PMCID]
11. Cai X, Yuan S, Zeng Y, Wang C, Yu N, Ding C. New Trends in Pharmacological Treatments for Osteoarthritis. Front Pharmacol. 2021;12:645842. [DOI] [PMID] [PMCID]
12. Mahir L, Belhaj K, Zahi S, Azanmasso H, Lmidmani F, El Fatimi A. Impact of knee osteoarthritis on the quality of life. Ann Phys Rehabil Med. 2016;59(Supplement):e159. [DOI]
13. Arthritis Foundation. Osteoarthritis. [Internet]. 2022. Available from:https://www.arthritis.org/diseases/osteoarthritis
14. Katz JN, Arant KR, Loeser RF. Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review. JAMA. 2021;325(6):568-78. [DOI] [PMID] [PMCID]
15. Ariana M, Afrasiabifar A, Najafi Doulatabad S, Mosavi A, Behnammoghadam M. The Effect of Local Heat Therapy versus Cold Rub Gel on Pain and Joint Functions in Patients with Knee Osteoarthritis. Clin Nurs Res. 2022;31(6):1014-22. [DOI] [PMID]
16. Richardson C, Plaas A, Block JA. Intra-articular hyaluronan therapy for symptomatic knee osteoarthritis. Rheum Dis Clin North Am. 2019;45(3):439-51. [DOI] [PMID]
17. Gao SH, Huo JB, Pan QM, Li XW, Chen HY, Huang JH. The short-term effect and safety of duloxetine in osteoarthritis: A systematic review and meta-analysis. Medicine (Baltimore). 2019;98(44):e17541. [DOI] [PMID] [PMCID]
18. Chen AT, Shrestha S, Collins JE, Sullivan JK, Losina E, Katz JN. Estimating contextual effect in nonpharmacological therapies for pain in knee osteoarthritis: a systematic analytic review. Osteoarthritis Cartilage. 2020;28(9):1154-69. [DOI] [PMID] [PMCID]
19. Żęgota Z, Goździk J, Głogowska-Szeląg J. Efficacy of herbal and naturallyderived dietary supplements for the management of knee osteoarthritis: A mini-review. Wiad Lek. 2021;74(8):1975-83. [DOI] [PMID]
20. Block JA, Cherny D. Management of Knee Osteoarthritis: What Internists Need to Know. Med Clin North Am. 2021;105(2):367-85. [DOI] [PMID]
21. 21. González-Trujano M, Peña E, Martínez A, Moreno J, Guevara-Fefer P, Deciga-Campos M, et al. Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. Journal of ethnopharmacology. 2007;111(3):476-82. [DOI]
22. Tahoonian-Golkhatmy F, Abedian Z, Emami SA, Esmaily H. Comparison of rosemary and mefenamic acid capsules on menstrual bleeding and primary dysmenorrhea: A clinical trial. Iran J Nurs Midwifery Res. 2019;24(4):301-5. [DOI] [PMID] [PMCID]
23. de Macedo LM, Santos ÉMd, Militão L, Tundisi LL, Ataide JA, Souto EB, et al. Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and Its Topical Applications: A Review. Plants (Basel). 2020;9(5):651. [DOI] [PMID] [PMCID]
24. González-Trujano ME, Peña EI, Martínez AL, Moreno J, Guevara-Fefer P, Déciga-Campos M, et al. Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents. J Ethnopharmacol. 2007;111(3):476-82. [DOI] [PMID]
25. Ghannadi A, Karimzadeh H, Tavakoli N, Darafsh M, Ramezanloo P. Efficacy of a combined rosemary and lavender topical ointment in the treatment of patients with osteoarthritis of the knee. Zahedan J Res Med Sci. 2013;15(6):29-33. [Article]
26. Mohammadifar M, Talaei SA, Vakili Z, Bahmani F, Memarzadeh MR, Aarabi MH. Eavaluating antinociceptic effect of nano-emulsion gel conataining rosemary and peppermint essential oils in a rat model of osteoarthritis. Scientific J Kurdistan Univ Med Sci. 2018;23(4):100-9. [Article]
27. Lukaczer D, Darland G, Tripp M, Liska D, Lerman RH, Schiltz B, et al. A Pilot trial evaluating meta050, a proprietary combination of reduced iso‐alpha acids, rosemary extract and oleanolic acid in patients with arthritis and fibromyalgia. Phytother Res. 2005;19(10):864-9. [DOI] [PMID]
28. Rosenbaum CC, O'Mathána DP, Chavez M, Shields K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern Ther Health Med. 2010;16(2):32-40. [PMID]
29. Scalfo F, Davis S, Lai A, Karsdal M, Offord E, Ameye LG. Rosemary extract slows down cartilage degeneration in bovine articular cartilage explants. J Hum Nutr Diet. 2009;22(3):270. [DOI]
30. Horcajada M-N, Sanchez C, Scalfo F, Ameye L, Henrotin Y, Offord E. 071 Effect of Rosemary Extract and Related Flavonoid Carnosol on Chondro-Protection and on the Bone-Cartilage Crosstalk. Osteoarthritis Cartilage. 2010;18(2):S38-9. [DOI]
31. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29(8):1039-49. [DOI] [PMID]
32. Setoodehzadeh F, Khammarnia M, Peyvand M. Health Integrated System in Iran: Opportunities and Constraints. J Health Sci Surveill Syst. 2021;9(3):206-7. [DOI]
33. McConnell S, Kolopack P, Davis AM. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC): a review of its utility and measurement properties. Arthritis Rheum. 2001;45(5):453-61. [DOI] [PMID]
34. Guo Y, Xie J, Li X, Yuan Y, Zhang L, Hu W, et al. Antidepressant Effects of Rosemary Extracts Associate With Anti-inflammatory Effect and Rebalance of Gut Microbiota. Front Pharmacol. 2018;9:1126. [DOI] [PMID] [PMCID]
35. Mohammadifar M, Aarabi MH, Aghighi F, Kazemi M, Vakili Z, Memarzadeh MR, et al. Anti-osteoarthritis potential of peppermint and rosemary essential oils in a nanoemulsion form: behavioral, biochemical, and histopathological evidence. BMC Complement Med Ther. 2021;21(1):57. [DOI] [PMID] [PMCID]
36. Elbahnasawy AS, Valeeva ER, El-Sayed EM, Rakhimov II. The Impact of Thyme and Rosemary on Prevention of Osteoporosis in Rats. J Nutr Metab. 2019;2019:1431384. [DOI] [PMID] [PMCID]
37. Barão Paixão VL, Freire de Carvalho J. Essential oil therapy in rheumatic diseases: A systematic review. Complement Ther Clin Pract. 2021;43:101391. [DOI] [PMID]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Occupational Health and Epidemiology

Designed & Developed by : Yektaweb