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Showing 2 results for Hypothyroidism
Mohammad-Taghi Rezayati, Ahmad-Reza Sayadi, Ziba Shaabani **, Shokoofeh Moghaddam, Azam Bagherizdaeh, Fereshteh Iranmanesh, Vahid Ehsani, Fahimeh Mohammadizadeh, Shima Bazaz, Abdollah Jafarzadeh,
Volume 10, Issue 3 (7-2021)
Abstract
Background: A fundamental duty of the immune system is to defend against infectious agents. Significant abnormalities were reported in immune parameters of hypothyroid and hyperthyroid patients. In this study, we aim to assess various quantities of antibodies against the tetanus toxin (anti-TT) in hypothyroid and hyperthyroid patients.
Materials and Methods: Anti-TT levels were measured in serum samples from 50 hypothyroid patients, 50 hyperthyroid patients, and 50 euthyroid individuals, using the ELISA method. Besides, the minimum protective quantity of anti-TT was considered 0.1 IU/mL.
Results: Seroprotective rates against tetanus were 100, 80, and 96.0 % in euthyroid, hypothyroid, and hyperthyroid groups with the means of 3.52 ± 0.31, 1.62 ± 0.21, and 4.07 ± 0.32 IU/ml, respectively. Accordingly, hypothyroid patients exhibited lower anti-TT levels and seroprotective rates than the euthyroid group (P < 0.001 and P<0.004, respectively). Besides, in the hypothyroid group, anti-TT quantities and seroprotective rates were lower than those in hyperthyroid individuals (P < 0.001 and P < 0.03, respectively).
Conclusions: The findings demonstrated lower immunity and higher susceptibility to tetanus in patients with hypothyroidism. However, more studies are needed to be conducted in this field to provide more data to be considered in health programs.
Hajar Vatankhah, Hassan Ahmadinia, Mina Asadikaram, Batool Rezaei, Mohsen Rezaeian, Zahra Jamali,
Volume 13, Issue 4 (12-2024)
Abstract
Background: Congenital hypothyroidism (CH) is one of the most common endocrine diseases in newborns. Epidemiologic studies are very important to carry out more preventive assessments. This study evaluated the prevalence of CH in Rafsanjan in southeast Iran during 2017-2019.
Materials and Methods: In this descriptive study, we used the data collected from the CH screening of newborns in Rafsanjan, Kerman Province, Iran. The study population was 18832 newborns who had undergone a CH screening program according to the standard CH screening protocol in a public health center from March 2017 to March 2019. Diagnosed CH cases were compared with healthy newborns using chi-square.
Results: Overall, among this population, 94 cases were diagnosed with CH during the years 2017 to 2019. The prevalence of CH in Rafsanjan city was 4.99 per 1000 live births during 3 years. The frequency of thyroid dysfunction in the mother and birth weight under 2500 were higher among the CH group than the non-CH group (P < 0.001).
Conclusions: The study findings showed that the frequency of thyroid dysfunction in the mother and birth weight under 2500 were higher among the CH group than the non-CH group. Further studies with individual data and longitudinal are suggested to be more confident about the causality of the association.
