Volume 10, Issue 3 (Summer 2021)                   JOHE 2021, 10(3): 134-139 | Back to browse issues page


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Rezayati M, Sayadi A, Shaabani ** Z, Moghaddam S, Bagherizdaeh A, Iranmanesh F, et al . Lower Serum Levels of Antibodies against Tetanus Toxin in Patients with Hypothyroidism. JOHE. 2021; 10 (3) :134-139
URL: http://johe.rums.ac.ir/article-1-440-en.html
1- BSc in Laboratory Sciences, Dept. of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Assistant Prof, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3- Assistant Prof, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- BSc in Laboratory Sciences, Pathobiological Laboratory, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- BSc in Biology, Dept. of Pathology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
6- MSc in Physiology, Dept. of Physiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
7- Professor, Dept. of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran & Dept. of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran. , jafarzadeh14@yahoo.com
Abstract:   (531 Views)
Background: A fundamental duty of the immune system is to defend against infectious agents. Significant abnormalities were reported in immune parameters of hypothyroid and hyperthyroid patients. In this study, we aim to assess various quantities of antibodies against the tetanus toxin (anti-TT) in hypothyroid and hyperthyroid patients. 
Materials and Methods: Anti-TT levels were measured in serum samples from 50 hypothyroid patients, 50 hyperthyroid patients, and 50 euthyroid individuals, using the ELISA method. Besides, the minimum protective quantity of anti-TT was considered 0.1 IU/mL.
Results: Seroprotective rates against tetanus were 100, 80, and 96.0 % in euthyroid, hypothyroid, and hyperthyroid groups with the means of 3.52 ± 0.31, 1.62 ± 0.21, and 4.07 ± 0.32 IU/ml, respectively. Accordingly, hypothyroid patients exhibited lower anti-TT levels and seroprotective rates than the euthyroid group (P < 0.001 and P<0.004, respectively). Besides, in the hypothyroid group, anti-TT quantities and seroprotective rates were lower than those in hyperthyroid individuals (P < 0.001 and P < 0.03, respectively).
Conclusions: The findings demonstrated lower immunity and higher susceptibility to tetanus in patients with hypothyroidism. However, more studies are needed to be conducted in this field to provide more data to be considered in health programs.
Keywords: Human [MeSH], Hypothyroidism [MeSH], Hyperthyroidism [MeSH], Antibody [MeSH], Tetanus toxin [MeSH],
** Correction: The Correct Name is Ziba Shabani. The Correct Affiliation is Associate Prof, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
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Short Report: Original Article | Subject: Epidemiology
Received: 2021/06/27 | Accepted: 2021/10/2 | ePublished: 2021/12/1

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