Journal of Occupational
Health and Epidemiology
Rafsanjan university Of medical sciences
Volume 13, Issue 2 (Spring 2024)
J Occup Health Epidemiol 2024, 13(2): 62-69 |
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Hemmatipour A, Jalakani R, Jahangirimehr A, Keikhaei B, Rokhafrooz D, Rasouli Ghahfarokhi S M. Comparing Hematological Indices of People with Iron Deficiency Anemia, Thalassemia Minor and Major, and Healthy People. J Occup Health Epidemiol 2024; 13 (2) :62-69
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Akram Hemmatipour1 
, Razieh Jalakani2 , Azam Jahangirimehr3 , Bijan Keikhaei4 , Darush Rokhafrooz5 , Seyedeh Moloud Rasouli Ghahfarokhi * 6
, Razieh Jalakani2 , Azam Jahangirimehr3 , Bijan Keikhaei4 , Darush Rokhafrooz5 , Seyedeh Moloud Rasouli Ghahfarokhi * 6
1- M.Sc. in Nursing, Dept. of Nursing, Abadan University of Medical Sciences, Abadan, Iran.
2- M.Sc. in Hematology, Dept. of Hematology and Blood Banking, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
3- M.Sc. in Biostatistics, Dept. of Public Health, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
4- Associate Prof., Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5- Associate Prof., Nursing Care Research Center in Chronic Diseases, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
6- M.Sc. in Nursing, Nursing Care Research Center in Chronic Diseases, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- M.Sc. in Hematology, Dept. of Hematology and Blood Banking, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
3- M.Sc. in Biostatistics, Dept. of Public Health, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
4- Associate Prof., Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5- Associate Prof., Nursing Care Research Center in Chronic Diseases, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
6- M.Sc. in Nursing, Nursing Care Research Center in Chronic Diseases, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Article history
Received: 2024/01/1
Accepted: 2024/04/20
ePublished: 2024/06/26
Accepted: 2024/04/20
ePublished: 2024/06/26
Subject:
Epidemiology
Abstract: (657 Views)
Background: This study aimed to evaluate three hematological indices in children and adolescents with iron deficiency anemia, thalassemia minor and major and healthy people.
Materials and Methods: In this descriptive cross-sectional study, 164 patients were selected based on the inclusion and exclusion criteria, and divided into four groups (n=41): iron deficiency anemia, thalassemia minor, thalassemia major, and healthy people. The results obtained from the tests were recorded in the patients' checklist. Mann-Whitney test, Wilcoxon test, ROC curve and area under the curve were adopted for data analysis using SPSS Statistics V21.0.
Results: The mean age of patients was 13.07±3.82 years, of which 100 (62.5%) were men. There is a significant difference due to the hemoglobin concentration (Hb) index in two-by-two comparison of the groups (P<0.001), but this difference was not seen between iron deficiency and thalassemia minor groups (P=0.159). This difference was substantial (P<0.001) in terms of mean corpuscular volume (MCV) index, although it was only seen between the iron deficiency and thalassemia major groups (P=0.225). Finally, this mean difference was reported in Serum ferritin index (P<0.001), but no difference was observed between healthy group and thalassemia minor group (P=0.802).
Conclusion: The results showed that there is a difference in meanHb, MCV, and Ferritin levels between the studied groups, and the Hb and Ferritin indices are favorable for iron deficiency anemia, and the Hb and MCV indices are favorable to distinguish the thalassemia minor and major from healthy people.
Materials and Methods: In this descriptive cross-sectional study, 164 patients were selected based on the inclusion and exclusion criteria, and divided into four groups (n=41): iron deficiency anemia, thalassemia minor, thalassemia major, and healthy people. The results obtained from the tests were recorded in the patients' checklist. Mann-Whitney test, Wilcoxon test, ROC curve and area under the curve were adopted for data analysis using SPSS Statistics V21.0.
Results: The mean age of patients was 13.07±3.82 years, of which 100 (62.5%) were men. There is a significant difference due to the hemoglobin concentration (Hb) index in two-by-two comparison of the groups (P<0.001), but this difference was not seen between iron deficiency and thalassemia minor groups (P=0.159). This difference was substantial (P<0.001) in terms of mean corpuscular volume (MCV) index, although it was only seen between the iron deficiency and thalassemia major groups (P=0.225). Finally, this mean difference was reported in Serum ferritin index (P<0.001), but no difference was observed between healthy group and thalassemia minor group (P=0.802).
Conclusion: The results showed that there is a difference in meanHb, MCV, and Ferritin levels between the studied groups, and the Hb and Ferritin indices are favorable for iron deficiency anemia, and the Hb and MCV indices are favorable to distinguish the thalassemia minor and major from healthy people.
Keywords: Ferritin [MeSH], Thalassemia Minor [MeSH], Beta-Thalassemia [MeSH], Iron Deficiency [MeSH], Hemoglobin Concentration [MeSH], Mean Corpuscular Volume [MeSH]
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