Volume 4, Number 4 (Autumn 2015)                   JOHE 2015, 4(4): 205-212 | Back to browse issues page


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Vazirinejad R, Khalili P, Rezaeian M, Jamalizadeh A, Puorkarami A. The impact of exposure to pesticides on the risk of gastrointestinal cancer among pistachio farmers; a case-control study. JOHE. 2015; 4 (4) :205-212
URL: http://johe.rums.ac.ir/article-1-151-en.html

MSc in Epidemiology Rafsanjan University Of Medical Sciences, Rafsanjan, Iran.
Abstract:   (492 Views)

Background: Gastrointestinal cancers are among the most common cancers in different communities. Gastrointestinal tract cancer is the most common cancer among Iranian men and the second common cancer among Iranian women. Due to the impact of environmental factors on the risk of gastrointestinal cancer and the increasing use of agricultural pesticides, this study aimed to investigate the effects of exposure to pesticides on gastrointestinal cancer among  pistachio farmers, Rafsanjan, Iran

Materials and Methods: In this case-control study, 79 patients with gastrointestinal cancer (cases) and 143 healthy people (controls) were studied. For each case, two people were selected as controls for each case  from  their neighbors and relatives. Data were  collected  using the study checklist which included demographic  information and specific items related to their exposure. Data were  analyzed using independent t-test, chi-square test, Fisher’s exact test, and logistic regression. 

Results: The risk of gastrointestinal cancer after controlling some confounding factors among individuals who were exposed to  spraying pesticides  for less than 10 days per year was 1.38 (CI: 0.70-2.71), and in individuals who were exposed to it for between 10 to 20 days per year was 1.71 (CI: 0.79-3.7). The difference was not statistically significant . However, for individuals who had this exposure for more than 20 days per year, the risk was increased to 8.53 (CI: 2.1-34.7) which was statistically significant (P = 0.004). Unexpected exposure to agricultural pesticides and living close to pistachio gardens, both significantly (P < 0.05) increased the risk of gastrointestinal cancers by 8.67 (CI: 1-75.71) and 2.7 (CI: 1.43-5.1), respectively. Among subjects who used  protective equipment, the risk of gastrointestinal cancer was statistically lower (OR = 0.18, 95%CI: 0.042-0.85) than this risk among people who did not use this equipment (P = 0.03).

Conclusions: Our findings showed that exposure to pesticides, in particular for long time, increased the risk of gastrointestinal cancer among pistachio farmers. Further studies in this area are recommended.

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Type of Study: Applicable | Subject: Physiology

1. Etemadi A, Sadjadi A, Semnani S, Nouraie SM, Khademi H, Bahadori M. Cancer registry in Iran: a brief overview. Arch Iran Med 2008; 11(5):577-80.
2. almasi A, shamsi M, eshrati B, farzam R, alimoradi K, rahmati L. The epidemiology of gastrointestinal cancers (Stomach, esophageal, colorectal) In Markazi province during 2005-2010. Journal of Neyshabur University of Medical Sciences 2014; 2(2):22-7.
3. Naghavi M. Death report from 23 provinces in Iran. 1st ed. Tehran: Ministry of Health and Medical Education; 2004.
4. Mosavi-Jarrahi A, Mohagheghi MA. Epidemiology of esophageal cancer in the high-risk population of Iran. Asian Pac J Cancer Prev 2006; 7(3):375-80.
5. Pourhoseingholi MA, Vahedi M, Moghimi-Dehkordi B, Pourhoseingholi A, Ghafarnejad F, Maserat E, et al. Burden of hospitalization for gastrointestinal tract cancer patients-Results from a cross-sectional study in Tehran. Asian Pac J Cancer Prev 2009; 10(1):107-10.
6. Sadjadi A, Nouraie M, Mohagheghi MA, Mousavi-Jarrahi A, Malekezadeh R, Parkin DM. Cancer occurrence in Iran in 2002, an international perspective. Asian Pac J Cancer Prev 2005; 6(3):359-63.
7. Ghadimi R, Taheri H, Suzuki S, Kashifard M, Hosono A, Esfandiary I. Host and environmental factors for gastric cancer in Babol, the Caspian Sea Coast, Iran. Eur J Cancer Prev 2007; 16(3):192-5.
8. Ramezani B, Hanifi A. Geographical distribution of gastric cancer in Guilan province. Journal of Environmental Science and Technology 2011; 13:81-93.
9. Blair A, Freeman LB. Epidemiologic studies in agricultural populations: observations and future directions. J Agromedicine 2009; 14(2):125-31.
10. Tavakolian Ferdosieyeh V, Karimifared M, Esmaeili A, Hassanshahi GH, Vazirinejad R. Pesticide induced complications among pistachio farmers: In the rural area of Rafsanjan, Iran (2010). Journal of Occupation Health and Epidmiology 2012; 1(2):111-7.
11. Salerno C, Carcagnì A, Sacco S, Palin LA, Vanhaecht K, Panella M, et al. An Italian population-based case-control study on the association between farming and cancer: are pesticides a plausible risk factor? Arch Environ Occup Health 2015; 71(3):147-56.
12. Alexander DD, Weed DL, Mink PJ, Mitchell ME. A weight-of-evidence review of colorectal cancer in pesticide applicators: the agricultural health study and other epidemiologic studies. Int Arch Occup Environ Health 2012; 85(7):715-45.
13. Yildirim M, Kaya V, Yildiz M, Demirpence O, Gunduz S, Dilli UD: Esophageal cancer, gastric cancer and the use of pesticides in the southwestern of Turkey. Asian Pac J Cancer Prev 2014; 15(6):2821-3.
14. Andreotti G, Freeman LEB, Hou L, Coble J, Rusiecki J, Hoppin JA, et al. Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort. Int J Cancer 2009; 124(10):2495-500
15. Rusiecki JA, De Roos A, Lee WJ, Dosemeci M, Lubin JH, Hoppin JA, et al. Cancer incidence among pesticide applicators exposed to atrazine in the Agricultural Health Study. J Natl Cancer Inst 2004; 96(18):1375-82.
16. Meyer A, Alexandre PC, Chrisman Jde R, Markowitz SB, Koifman RJ, Koifman S. Esophageal cancer among brazilian agricultural workers: case-control study based on death certificates. Int J Hyg Environ Health 2011; 214(2):151-5
17. Andreotti G, Freeman LE, Hou L, Coble J, Rusiecki J, Hoppin JA, et al. Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort. Int J Cancer 2009; 124(10):2495-500.
18. Lee WJ, Alavanja MC, Hoppin JA, Rusiecki JA, Kamel F, Blair A, et al. Mortality among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. Environ Health Perspect 2007; 115(4):528-34
19. Samanic C, Rusiecki J, Dosemeci M, Hou L, Hoppin JA, Sandler DP, et al. Cancer incidence among pesticide applicators exposed to dicamba in the Agricultural Health Study. Environ Health Perspect 2006; 114(10):1521-6.
20. Van Bemmel DM, Visvanathan K, Beane-Freeman LE, Coble J, Hoppin J, Alavanja MC. S-ethyl-N, Ndipropylthiocarbamate exposure and cancer incidence among male pesticide applicators in the agricultural health study: a prospective cohort. Environ Health Perspect 2008; 116(11):1541-6.
21. Koutros S, Lynch CF, Ma X, Lee WJ, Hoppin JA, Christensen CH, et al. Heterocyclic aromatic amine pesticide use and human cancer risk: results from the U.S. Agricultural Health Study. Int J Cancer 2009; 124(5):1206-12.
22. Weichenthal S, Moase C, Chan P. A review of pesticide exposure and cancer incidence in the Agricultural Health Study cohort. Environ Health Perspect 2010; 118(8):1117-25.
23. Amizadeh M, Askari Saryazdi G. Effects of endosulfan on human health. WebmedCentral TOXICOLOGY 2011; 2(12):WMC002617. doi: 10.9754/journal.wmc.2011.002617.
24. Mannan S. The effects of endosulfan on human MCF-7 breast cancer cells. [MSc Thesis]. Oshawa: University of Ontario Institute of Technology; 2011.
25. Reynolds P, Hurley SE, Gunier RB, Yerabati S, Quach T, Hertz A. Residential proximity to agricultural pesticide use and incidence of breast cancer in the California, 1988-1997. Environ Res 2005; 113(8):993-1000.
26. Zare S, Behzadi M, Tarzanan M, Mohamadi MB, Omidi L, Heydarabadi AB, et al. The impacts of pesticides on the health of farmers in Fasa, Iran. Electron Physician 2015; 7(4):1168-73.

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