Journal of Occupational
Health and Epidemiology
Rafsanjan university Of medical sciences
Volume 7, Issue 4 (Autumn 2018)
J Occup Health Epidemiol 2018, 7(4): 233-239 |
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Akhondipour M, Faghihi Zarandi A, Amirri A, Gommnami N, Vazirinejad R. Studying the toxicity of molybdenum trioxide nanoparticles in male Wister rats. J Occup Health Epidemiol 2018; 7 (4) :233-239
URL: http://johe.rums.ac.ir/article-1-290-en.html
URL: http://johe.rums.ac.ir/article-1-290-en.html
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1- School of Health, Kerman University of Medical Sciences, Tehran, Iran.
2- Department of Occupational Health, Kerman University of Medical Sciences, Kerman, Iran.
3- Department of Chemistry, Payame Noor University, Tehran, Iran.
4- Medical School, Islamic Azad University, Mashhad Branch, Mashhad, Iran. ,gommnami_nasser@yahoo.com
5- Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Department of Occupational Health, Kerman University of Medical Sciences, Kerman, Iran.
3- Department of Chemistry, Payame Noor University, Tehran, Iran.
4- Medical School, Islamic Azad University, Mashhad Branch, Mashhad, Iran. ,
5- Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Article history
Received: 2018/01/30
Accepted: 2018/12/10
ePublished: 2019/02/13
Accepted: 2018/12/10
ePublished: 2019/02/13
Subject:
Occupational Health
Abstract: (4091 Views)
Background: With the spread of nanotechnology, various nanoparticles with new and emerging properties have been produced and the potential toxic effects of the majority of these particles remains still unknown. The present study was conducted to determine the toxicity of Molybdenum Trioxide nanoparticles in blood and body tissues of male Wistar rats.
Materials and Methods: Thirty Wistar rats with an average weight of 200±10 g were included in the present experimental study; the rats were divided into three groups of control, low dose intervention and high dose intervention. Nano-trioxide molybdenum was injected at 5 and 10 mg/kg body weight for 28 days; then, blood samples and rats organs were collected to measure the molybdenum content. Molybdenum concentration was measured by atomic absorption method. The collected data were analyzed using SPSS (Version 20) and appropriate statistical methods including one-way ANOVA were used in order to compare the mean of blood variables among the groups.
Results: The results showed that decreasing hematocrit (p <0.001), hemoglobin (p <0.001), and red and white blood cells (p <0.01) in rates receiving 10 mg of Molybdenum trioxide nanoparticles was significantly higher than that among rates in the other two groups. The mean degradation of molybdenum trioxide nanoparticles in the liver and kidneys was significantly higher than the heart and stomach (p <0.05).
Conclusion: The results of the study showed that molybdenum trioxide nanoparticles at high concentrations had a more toxic effect on blood and serum parameters in comparison with the low concentrations.
Materials and Methods: Thirty Wistar rats with an average weight of 200±10 g were included in the present experimental study; the rats were divided into three groups of control, low dose intervention and high dose intervention. Nano-trioxide molybdenum was injected at 5 and 10 mg/kg body weight for 28 days; then, blood samples and rats organs were collected to measure the molybdenum content. Molybdenum concentration was measured by atomic absorption method. The collected data were analyzed using SPSS (Version 20) and appropriate statistical methods including one-way ANOVA were used in order to compare the mean of blood variables among the groups.
Results: The results showed that decreasing hematocrit (p <0.001), hemoglobin (p <0.001), and red and white blood cells (p <0.01) in rates receiving 10 mg of Molybdenum trioxide nanoparticles was significantly higher than that among rates in the other two groups. The mean degradation of molybdenum trioxide nanoparticles in the liver and kidneys was significantly higher than the heart and stomach (p <0.05).
Conclusion: The results of the study showed that molybdenum trioxide nanoparticles at high concentrations had a more toxic effect on blood and serum parameters in comparison with the low concentrations.
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