Journal of Occupational
Health and Epidemiology
Rafsanjan university Of medical sciences
Volume 12, Issue 2 (Spring 2023)
J Occup Health Epidemiol 2023, 12(2): 90-97 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Tajpoor A, Nadri F, Khavanin * A, Vosooghi S, Nadri H, Zare S. Simultaneous Effect of Noise Stress and Opium Addiction on Adult Rat Sperm Parameters: An Experimental Study. J Occup Health Epidemiol 2023; 12 (2) :90-97
URL: http://johe.rums.ac.ir/article-1-605-en.html
URL: http://johe.rums.ac.ir/article-1-605-en.html
Related article in
Google Scholar
Google Scholar
Similar articles
1- M.Sc in Occupational Health Engineering, Dept. of Occupational Health Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2- Assisstant Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. , nadrifarshad64@gmail.com
3- Professor in Occupational Health Engineering, Dept. of Occupational Health Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
4- Associate Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Iran University of Medical Sciences, Tehran, Iran.
5- Assisstant Prof., in Occupational Health, Dept. of Occupational Health Engineering, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
6- Associate Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Kerman University of Medical Sciences, Kerman, Iran.
2- Assisstant Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. , nadrifarshad64@gmail.com
3- Professor in Occupational Health Engineering, Dept. of Occupational Health Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
4- Associate Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Iran University of Medical Sciences, Tehran, Iran.
5- Assisstant Prof., in Occupational Health, Dept. of Occupational Health Engineering, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran.
6- Associate Prof., in Occupational Health, Dept. of Occupational Health Engineering, Faculty of Health, Kerman University of Medical Sciences, Kerman, Iran.
Article history
Received: 2022/06/14
Accepted: 2023/02/22
ePublished: 2023/06/28
Accepted: 2023/02/22
ePublished: 2023/06/28
Subject:
Occupational Health
Abstract: (413 Views)
Background: There are considerable opium addicts, particularly among workers in Iran's industrial sectors. This study aimed to investigate the effects of simultaneous exposure to excessive noise and opium addiction on adult rat sperm parameters.
Materials and Methods: In this experimental study 42 adult Wistar male rats in 6 groups were studied as follows: group 1 control, group 2 exposed to noise (100 dB) 8 h/day, group 3 received daily 50 mg/case opium solution, group 4 received daily 100 mg/case opium solution, group 5 received daily 50 mg/case opium solution and exposed to noise 8h/day, and group 6 received daily 100 mg/case opium solution and exposed to noise 8h/day. After 50 days, cauda epididymis was removed for sperm parameters examination (WHO guidelines).
Results: In the groups receiving opium (50 and 100 mg/case), sperm count, sperm viability, and normal sperm morphology (%) significantly decreased compared to the control group. Exposure to noise and consumption of opium solution simultaneously significantly reduced the count, viability, and percentage of sperm with normal morphology in both selected doses, as well as a significant difference between groups 5 and 6 in count, viability, and normal sperm morphology(%) parameters(P<0.05).
Conclusions: According to the results, noise exposure and taking opium would actively reduce the count, viability, and normal sperm morphology. It is therefore suggested that the mechanism of such effects should be investigated in animal and human studies.
Materials and Methods: In this experimental study 42 adult Wistar male rats in 6 groups were studied as follows: group 1 control, group 2 exposed to noise (100 dB) 8 h/day, group 3 received daily 50 mg/case opium solution, group 4 received daily 100 mg/case opium solution, group 5 received daily 50 mg/case opium solution and exposed to noise 8h/day, and group 6 received daily 100 mg/case opium solution and exposed to noise 8h/day. After 50 days, cauda epididymis was removed for sperm parameters examination (WHO guidelines).
Results: In the groups receiving opium (50 and 100 mg/case), sperm count, sperm viability, and normal sperm morphology (%) significantly decreased compared to the control group. Exposure to noise and consumption of opium solution simultaneously significantly reduced the count, viability, and percentage of sperm with normal morphology in both selected doses, as well as a significant difference between groups 5 and 6 in count, viability, and normal sperm morphology(%) parameters(P<0.05).
Conclusions: According to the results, noise exposure and taking opium would actively reduce the count, viability, and normal sperm morphology. It is therefore suggested that the mechanism of such effects should be investigated in animal and human studies.
References
1. Ahmadi R, Ahmadifar M, Safarpour E, Vahidi-Eyrisofla N, Darab M, Eini AM, et al. The effects of levofloxacin on testis tissue and spermatogenesis in rat. Cell J. 2016;18(1):112-6. [DOI] [PMID] [PMCID]
2. Ustinkina TI. Environmental factors in disorders in male reproductive Function. Reprod Toxicol. 1993;7(5):520. [DOI]
3. Veeramachaneni DN. Impact of environmental pollutants on the male: effects on germ cell differentiation. Anim Reprod Sci. 2008;105(1-2):144-57. [DOI] [PMID] [PMCID]
4. Thonneau P, Bujan L, Multigner L, Mieusset R. Occupational heat exposure and male fertility: a review. Hum Reprod. 1998;13(8):2122-5. [DOI] [PMID]
5. Phillips KP, Tanphaichitr N. Mechanisms of obesity-induced male infertility. Expert Rev Endocrinol Metab. 2010;5(2):229-51. [DOI] [PMID]
7. Zare S, Nassiri P, Monazzam MR, Pourbakht A, Azam K, Golmohammadi T. Evaluation of the effects of occupational noise exposure on serum aldosterone and potassium among industrial workers. Noise Health. 2016; 18(80):1-6. [DOI] [PMID] [PMCID]
8. Ascari E, Licitra G, Ancona C, Badaloni C, Mattei F, Gagliardi P. Noise pollution from road traffic noise in Rome: Incidence of coronary and cardiovascular events. Proc Meet Acoust. 2017;30(1):040008. [DOI]
9. Gao Y, Chen F, Kong QQ, Ning SF, Yuan HJ, Lian HY, et al. Stresses on female mice impair oocyte developmental potential: effects of stress severity and duration on oocytes at the growing follicle stage. Reprod Sci. 2016;23(9):1148-57. [DOI] [PMID]
10. Nadri F, Khavanin A, Mazaheri Z, Soleimanian A. Effect of noise pollution on male fertility (Review). J Occup Health Epimiol. 2016;5(1):53-62. [DOI]
11. Bisong SA, Ukoh IE, Nna VU, Ebong PE. Vitamin E attenuates nicotine‐and noise‐induced reproductive impairment in male albino Wistar rats. Andrologia. 2018;50(7):e13050. [DOI] [PMID]
12. Sadeghian S, Darvish S, Davoodi G, Salarifar M, Mahmoodian M, Fallah N, et al. The association of opium with coronary artery disease. Eur J Cardiovasc Prev Rehabil. 2007;14(5):715-7. [DOI] [PMID]
13. Kouros D, Tahereh H, Mohammadreza A, Minoo MZ. Opium and heroin alter biochemical parameters of human's serum. Am J Drug Alcohol Abuse. 2010;36(3):135-9. [DOI] [PMID]
14. Gozashti MH, Mohammadzadeh E, Divsalar K, Shokoohi M. The effect of opium addiction on thyroid function tests. J Diabetes Metab Disord. 2014;13(1):5. [DOI] [PMID] [PMCID]
15. Najafipour H, Beik A. The impact of opium consumption on blood glucose, serum lipids and blood pressure, and related mechanisms. Front Physiol. 2016;7:436. [DOI] [PMID] []
16. Mohammadi A, Darabi M, Nasry M, Saabet-Jahromi MJ, Malek-Pour-Afshar R, Sheibani H. Effect of opium addiction on lipid profile and atherosclerosis formation in hypercholesterolemic rabbits. Exp Toxicol Pathol. 2009;61(2):145-9. [DOI] [PMID]
17. Amin‐Esmaeili M, Rahimi‐Movaghar A, Sharifi V, Hajebi A, Radgoodarzi R, Mojtabai R, et al. Epidemiology of illicit drug use disorders in Iran: prevalence, correlates, comorbidity and service utilization results from the Iranian Mental Health Survey. Addiction. 2016;111(10):1836-47. [DOI] [PMID]
18. Mehrpour O, Sheikhazadi A, Barzegar A, Husein A, Malic C, Sheikhazadi E, et al. Comparison of quantitative and qualitative dermatoglyphic characteristics of opium addicts with healthy individuals. Addict Health. 2016;8(2):76-83. [PMID] [PMCID]
19. Alavi S, Mehrdad R, Makarem J. Prevalence of substance abuse/alcohol consumption and their predictors among patients admitted in operating rooms of a General Educational Hospital, Tehran, Iran. Asian J Pharm Res Health Care. 2016;8(S1):63-71. [Article] [DOI]
20. Buchbauer G, Nikiforov A, Remberg B. Headspace constituents of opium. Planta Med. 1994; 60(2):181-3. [DOI] [PMID]
21. Asiabanha M, Asadikaram G, Rahnema A, Mahmoodi M, Hasanshahi G, Hashemi M, et al. Chronic opium treatment can differentially induce brain and liver cells apoptosis in diabetic and non-diabetic male and female rats. Korean J Physiol Pharmacol. 2011;15(6):327-32. [DOI] [PMID] [PMCID]
22. Rahmati A, Shakeri R, Khademi H, Poutschi H, Pourshams A, Etemadi A, et al. Mortality from respiratory diseases associated with opium use: a population-based cohort study. Thorax. 2017; 72(11):1028-34. [DOI] [PMID] [PMCID]
23. Nematollahi-Mahani SN, Labibi F, Shahidzadeh Yazdi Z, Karamad E, Habibzadeh V, Naderi T, et al. The impact of opium dependence and cigarette smoking on human semen parameters. Anat Sci J. 2014;11(4):189-96. [Article]
24. Cyrus A, Solhi H, Azizabadi Farahani M, Khoddami Vishteh HR, Goudarzi D, Mosayebi G, et al. The effect of opium dependency on testis volume: a case-control study. Iran J Reprod Med. 2012;10(6):517-22. [PMID] [PMCID]
25. Cicero TJ. Effects of exogenous and endogenous opiates on the hypothalamic--pituitary--gonadal axis in the male. Fed Proc. 1980;39(8):2551-4. [PMID]
26. Safarinejad MR, Asgari SA, Farshi A, Ghaedi G, Kolahi AA, Iravani S, et al. The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity. Reprod Toxicol. 2013; 36:18-23. [DOI] [PMID]
27. Cicero TJ, Davis LA, LaRegina MC, Meyer ER, Schlegel MS. Chronic opiate exposure in the male rat adversely affects fertility. Pharmacol Biochem Behav. 2002;72(1-2):157-63. [DOI] [PMID]
28. Guide for the care and use of laboratory animals. 8th ed. Washington (DC), United States: National Academies Press; 2011.
29. Ghanbari M, Mortazavi SB, Khavanin A, Khazaei M. Simultaneous effects of exposure to microwaves and noise on male rat'sperm parameters and total antioxidant capacity. Health Scope. 2012;1(4):e93536. [DOI]
30. Greenebaum B, Barnes F. Biological and medical aspects of electromagnetic fields. 4th ed. Florida, United States: CRC Press; 2019.
31. Faridan M, Khavanin A, Mirzaei R, Salehnia M. The Effects of Normobaric Hyperoxia Pre- and Post-treatment on the Development of Noise-Induced Hearing Loss in Rats. Health Scope. 2017;6(4):e63169. [DOI]
32. Diab A, Hendawy A, Asala AK, Ibrahim SS, Hassan MA. Effect of Noise Stress on pituitary gonadal axis in albino rats. J Am Sci. 2012;8(11):198-202.
33. Ruffoli R, Carpi A, Giambelluca MA, Grasso L, Scavuzzo MC, Giannessi FF. Diazepam administration prevents testosterone decrease and lipofuscin accumulation in testis of mouse exposed to chronic noise stress. Andrologia. 2006;38(5):159-65. [DOI] [PMID]
34. Swami CG, Ramanathan J, Charan Jeganath C. Noise exposure effect on testicular histology, morphology and on male steroidogenic hormone. Malays J Med Sci. 2007;14(2):28-35. [PMID] [PMID]
35. Vosoughi S, Khavanin A, Salehnia M, Asilian Mahabadi H, Soleimanian A. Effects of simultaneous exposure to formaldehyde vapor and noise on mouse testicular tissue and sperm parameters. Health Scope. 2012;1(3):110-7. [DOI]
36. Taban E, Mortazavi SB, Vosoughi S, Khavanin A, Asilian Mahabadi H. Noise Exposure Effects on Blood Glucose, Cortisol and Weight Changes in the Male Mice. Health Scope. 2017;6(2):e36108. [DOI]
37. Kelly JB, Masterton B. Auditory sensitivity of the albino rat. J Comp Physiol Psychol. 1977;91(4):930-6. [DOI] [PMID]
38. Campo P, Pouyatos B, Lataye R, Morel G. Is the aged rat ear more susceptible to noise or styrene damage than the young ear? Noise Health. 2003;5(19):1-18. [PMID]
39. Lataye R, Campo P, Loquet G. Combined effects of noise and styrene exposure on hearing function in the rat. Hear Res. 2000;139(1-2):86-96. [DOI] [PMID]
40. Cobo P, Murillo-Cuesta S, Cediel R, Moreno A, Lorenzo-García P, Varela- Nieto I. Design of a reverberant chamber for noise exposure experiments with small animals. Appl Acoust. 2009;70(8):1034-40. [DOI]
41. Mami S, Eghbali M, Khosravi A, Purmehdi Brojeni M, Salati A, Mami F, et al. Effect of opium addiction on T4, T3 and TSH in male and female rats. J Ilam Univ Med Sci. 2012;20(2):17-22. [Article]
42. Asadikaram GR, Asiabanha M, Rahnema A, Shaebani Shahrbabaki Z, Mahmoodi M, Sasan H. Testicular Cells Apoptosis in Opium-Addicted Rats. J Rafsanjan Univ Med Sci. 2011; 10(3):231-6. [Article]
43. World Health Organization. WHO laboratory manual for the examination and processing of human semen. Geneva, Switzerland: World Health Organization; 2021. [Report]
44. Jalali M, Saki G, Sarkaki AR, Karami K, Nasri S. Effect of noise stress on count, progressive and non-progressive sperm motility, body and genital organ weights of adult male rats. J Hum Reprod Sci. 2012;5(1):48-51. [DOI] [PMID] []
45. Aghaei S, Nikzad H, Taghizadeh M, Tameh AA, Taherian A, Moravveji A. Protective effect of Pumpkin seed extract on sperm characteristics, biochemical parameters and epididymal histology in adult male rats treated with Cyclophosphamide. Andrologia. 2014;46(8):927-35. [DOI] [PMID]
46. Pramanik P, Biswas S. Traffic noise: a silent killer of male gamete of albino rats. Al Ameen J Med Sci. 2012;5(1):82-9. [Article]
47. Asadi MH, Zafari F, Sarveazad A, Abbasi M, Safa M, Koruji M, et al. Saffron improves epididymal sperm parameters in rats exposed to cadmium. Nephrourol Mon. 2013;6(1):e12125. [DOI] [PMID] [PMID]
48. Shahramian E, Moradi A, Moein AA, Rakhshani M, Badakhsh M. Semen evaluation in opium addicts and non addicts: A case-control study. Yafteh. 2007;8(4):49-54. [Article]
49. Assaei R, Nazari H, Pajouhi N, Zahedi-Asl S. Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency. Zahedan J Res Med Sci. 2013;15(4):53-5. [Article]
50. Amin YK. The relation of opium addiction and reproductive toxicity in male rats: a histological and hormonal study. Zanco J Med Sci. 2013;17(1):311-6. [DOI]
51. Nadri F, Khavanin A, Mazaheri Z, Khajehnasiri F. The Effect of Noise Stress on Adult Male Rat Sperm Parameters and the Protective Effect of Hydroalcoholic Cinnamomum verum Extract: An Experimental Study. Iran Red Crescent Med J. 2018;20(12):e69779. [DOI]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
