Journal of Occupational
Health and Epidemiology
Rafsanjan university Of medical sciences
Volume 12, Issue 2 (Spring 2023)
J Occup Health Epidemiol 2023, 12(2): 114-122 |
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Hashemi Habybabady R, Mohammadi M, Jafari H, Paridokht F. Protective Effect of N-Acetylcysteine against Continuous Noise-Induced Hearing Loss. J Occup Health Epidemiol 2023; 12 (2) :114-122
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URL: http://johe.rums.ac.ir/article-1-675-en.html
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1- Assistant Prof., Health Promotion Research Center, Dept. of Occupational Health Engineering , Zahedan University of Medical Sciences, Zahedan, Iran.
2- Professor in Biostatistics, Dept. of Biostatistics & Epidemiology , Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. ,memohammadi@yahoo.com
3- M.Sc in Occupational Health Engineering, Research Assistant, Occupational Health Engineering, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
4- M.Sc in Occupational Health and Safety Engineering, Dept. of Occupational Health and Safety Engineering, Student Research Committee, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
2- Professor in Biostatistics, Dept. of Biostatistics & Epidemiology , Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. ,
3- M.Sc in Occupational Health Engineering, Research Assistant, Occupational Health Engineering, Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
4- M.Sc in Occupational Health and Safety Engineering, Dept. of Occupational Health and Safety Engineering, Student Research Committee, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Article history
Received: 2023/01/3
Accepted: 2023/05/30
ePublished: 2023/06/28
Accepted: 2023/05/30
ePublished: 2023/06/28
Subject:
Occupational Health
Abstract: (821 Views)
Background: This study aimed to determine the preventive effect of N-Acetylcysteine (NAC) against continuous noise-induced hearing loss.
Materials & Methods: A total of 24 adult male Wistar rats were randomly assigned into 4 groups of 6 animals: control, noise, noise and NAC, noise and saline. Animals were subjected to 102 dB (102±0.5) of continuous, 8 kHz-centered high pass white noise. For two days before to noise, one hour prior to noise for ten days in a row, and two days after noise, NAC (325 mg/kg) was intraperitoneally administered. Temporary and permanent hearing loss were assessed by pre and post noise (1, 7 and 21 days) recordings of distortion product otoacoustic emissions (DPOAEs).
Results: Amplitudes was temporally reduced significantly first day post noise exposure in all groups, and all frequencies (P<0.05). The initial and subsequent recovery was more pronounced in noise-exposed animal treated with NAC compared to those received noise and saline, especially in higher frequencies (P<0.05). Noise and NAC group experienced less permanent hearing loss than noise and saline group (P<0.05).
Conclusions: NAC could partially improve permanent hearing loss after noise exposure However, temporary hearing loss was not affected by NAC.
Materials & Methods: A total of 24 adult male Wistar rats were randomly assigned into 4 groups of 6 animals: control, noise, noise and NAC, noise and saline. Animals were subjected to 102 dB (102±0.5) of continuous, 8 kHz-centered high pass white noise. For two days before to noise, one hour prior to noise for ten days in a row, and two days after noise, NAC (325 mg/kg) was intraperitoneally administered. Temporary and permanent hearing loss were assessed by pre and post noise (1, 7 and 21 days) recordings of distortion product otoacoustic emissions (DPOAEs).
Results: Amplitudes was temporally reduced significantly first day post noise exposure in all groups, and all frequencies (P<0.05). The initial and subsequent recovery was more pronounced in noise-exposed animal treated with NAC compared to those received noise and saline, especially in higher frequencies (P<0.05). Noise and NAC group experienced less permanent hearing loss than noise and saline group (P<0.05).
Conclusions: NAC could partially improve permanent hearing loss after noise exposure However, temporary hearing loss was not affected by NAC.
Keywords: N-Acetylcysteine [MeSH], Noise [MeSH], Temporary [MeSH], Permanent [MeSH], Hearing Loss [MeSH]
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