Journal of Occupational
Health and Epidemiology
Rafsanjan university Of medical sciences
Volume 10, Issue 3 (Summer 2021)
J Occup Health Epidemiol 2021, 10(3): 134-139 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Rezayati M, Sayadi A, Shaabani ** Z, Moghaddam S, Bagherizdaeh A, Iranmanesh F, et al . Lower Serum Levels of Antibodies against Tetanus Toxin in Patients with Hypothyroidism. J Occup Health Epidemiol 2021; 10 (3) :134-139
URL: http://johe.rums.ac.ir/article-1-440-en.html
URL: http://johe.rums.ac.ir/article-1-440-en.html
Related article in
Google Scholar
Google Scholar
Similar articles
Mohammad-Taghi Rezayati1 
, Ahmad-Reza Sayadi2 , Ziba Shaabani **3 , Shokoofeh Moghaddam4 , Azam Bagherizdaeh4 , Fereshteh Iranmanesh5 , Vahid Ehsani6 , Fahimeh Mohammadizadeh4 , Shima Bazaz4 , Abdollah Jafarzadeh * 7
, Ahmad-Reza Sayadi2 , Ziba Shaabani **3 , Shokoofeh Moghaddam4 , Azam Bagherizdaeh4 , Fereshteh Iranmanesh5 , Vahid Ehsani6 , Fahimeh Mohammadizadeh4 , Shima Bazaz4 , Abdollah Jafarzadeh * 7
1- BSc in Laboratory Sciences, Dept. of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Assistant Prof, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3- Assistant Prof, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- BSc in Laboratory Sciences, Pathobiological Laboratory, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- BSc in Biology, Dept. of Pathology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
6- MSc in Physiology, Dept. of Physiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
7- Professor, Dept. of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran & Dept. of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran. ,jafarzadeh14@yahoo.com
2- Assistant Prof, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3- Assistant Prof, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
4- BSc in Laboratory Sciences, Pathobiological Laboratory, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- BSc in Biology, Dept. of Pathology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
6- MSc in Physiology, Dept. of Physiology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
7- Professor, Dept. of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran & Dept. of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran. ,
Article history
Received: 2021/06/27
Accepted: 2021/10/2
ePublished: 2021/09/28
Accepted: 2021/10/2
ePublished: 2021/09/28
Subject:
Epidemiology
Abstract: (1790 Views)
Background: A fundamental duty of the immune system is to defend against infectious agents. Significant abnormalities were reported in immune parameters of hypothyroid and hyperthyroid patients. In this study, we aim to assess various quantities of antibodies against the tetanus toxin (anti-TT) in hypothyroid and hyperthyroid patients.
Materials and Methods: Anti-TT levels were measured in serum samples from 50 hypothyroid patients, 50 hyperthyroid patients, and 50 euthyroid individuals, using the ELISA method. Besides, the minimum protective quantity of anti-TT was considered 0.1 IU/mL.
Results: Seroprotective rates against tetanus were 100, 80, and 96.0 % in euthyroid, hypothyroid, and hyperthyroid groups with the means of 3.52 ± 0.31, 1.62 ± 0.21, and 4.07 ± 0.32 IU/ml, respectively. Accordingly, hypothyroid patients exhibited lower anti-TT levels and seroprotective rates than the euthyroid group (P < 0.001 and P<0.004, respectively). Besides, in the hypothyroid group, anti-TT quantities and seroprotective rates were lower than those in hyperthyroid individuals (P < 0.001 and P < 0.03, respectively).
Conclusions: The findings demonstrated lower immunity and higher susceptibility to tetanus in patients with hypothyroidism. However, more studies are needed to be conducted in this field to provide more data to be considered in health programs.
Materials and Methods: Anti-TT levels were measured in serum samples from 50 hypothyroid patients, 50 hyperthyroid patients, and 50 euthyroid individuals, using the ELISA method. Besides, the minimum protective quantity of anti-TT was considered 0.1 IU/mL.
Results: Seroprotective rates against tetanus were 100, 80, and 96.0 % in euthyroid, hypothyroid, and hyperthyroid groups with the means of 3.52 ± 0.31, 1.62 ± 0.21, and 4.07 ± 0.32 IU/ml, respectively. Accordingly, hypothyroid patients exhibited lower anti-TT levels and seroprotective rates than the euthyroid group (P < 0.001 and P<0.004, respectively). Besides, in the hypothyroid group, anti-TT quantities and seroprotective rates were lower than those in hyperthyroid individuals (P < 0.001 and P < 0.03, respectively).
Conclusions: The findings demonstrated lower immunity and higher susceptibility to tetanus in patients with hypothyroidism. However, more studies are needed to be conducted in this field to provide more data to be considered in health programs.
Keywords: Human [MeSH], Hypothyroidism [MeSH], Hyperthyroidism [MeSH], Antibody [MeSH], Tetanus toxin [MeSH]
** Correction: The Correct Name is Ziba Shabani. The Correct Affiliation is Associate Prof, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
** Correction: The Correct Name is Ziba Shabani. The Correct Affiliation is Associate Prof, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
References
2. Uket HO, Ekanem EE, Okpara HC, Ekrikpo UE. Comparative tetanus antibody response of Nigerian children to diphtheria-pertussis-tetanus and pentavalent vaccines. Niger Postgrad Med J 2018; 25(3):137-42. [DOI] [PMID]
3. Reed DB, Westneat SC. Exposure risks and tetanus immunization status in farmers ages 50 and over. South Med J 2009; 102(3):251-5. [DOI] [PMID]
4. Liang JL, Tiwari T, Moro P, Messonnier NE, Reingold A, Sawyer M, et al. Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2018; 67(2):1-44. [DOI] [PMID] [PMCID]
5. Choi JH, Choo EJ, Huh A, Choi SM, Eom JS, Lee JS, et al. Immunogenicity and safety of diphtheria-tetanus vaccine in adults. J Korean Med Sci 2010; 25(12):1727-32. [DOI] [PMID] [PMCID]
6. Zarei S, Jeddi-Tehrani M, Akhondi MM, Zeraati H, Kheirkhah T, Ghazanfari M, et al. Immunogenicity of a triple diphtheria-tetanus-whole cell pertussis vaccine in Iranian preschool children. Iran J Immunol 2007; 4(2):101-9. [PMID]
7. Taylor PN, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus JH, Dayan CM, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol 2018; 14(5):301-16. [DOI] [PMID]
8. Amouzegar A, Ghaemmaghami Z, Beigy M, Gharibzadeh S, Mehran L, Tohidi M, et al. Natural Course of Euthyroidism and Clues for Early Diagnosis of Thyroid Dysfunction: Tehran Thyroid Study. Thyroid 2017; 27(5):616-25. [DOI] [PMID]
9. Jara EL, Munoz-Durango N, Llanos C, Fardella C, Gonzalez PA, Bueno SM, et al. Modulating the function of the immune system by thyroid hormones and thyrotropin. Immunol Lett 2017; 184:76-83. [DOI] [PMID]
10. Jafarzadeh A, Poorgholami M, Izadi N, Nemati M, Rezayati M. Immunological and hematological changes in patients with hyperthyroidism or hypothyroidism. Clin Invest Med 2010; 33(5):E271-9. [DOI] [PMID]
11. Safdari V, Alijani E, Nemati M, Jafarzadeh A. Imbalances in T Cell-Related Transcription Factors among Patients with Hashimoto's Thyroiditis. Sultan Qaboos Univ Med J 2017; 17(2):e174-e80. [DOI] [PMID] [PMCID]
12. Koulouri O, Gurnell M. How to interpret thyroid function tests. Clin Med (Lond) 2013; 13(3):282-6. [DOI] [PMID] [PMCID]
13. Jafarzadeh A, Shabani Z, Hassanabadi M, Rezayati MT, Nemati M, Sayadi AR, et al. Lower immunity to tetanus in cigarette smoker subjects. J Occu Health Epidemiol 2012; 1(3):124-31. [DOI]
14. Stebegg M, Kumar SD, Silva-Cayetano A, Fonseca VR, Linterman MA, Graca L. Regulation of the Germinal Center Response. Front Immunol 2018; 9:2469. [DOI] [PMID] [PMCID]
15. Dorshkind K, Horseman ND. The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocr Rev 2000; 21(3):292-312. [DOI] [PMID]
16. Castellino F, Galli G, Del Giudice G, Rappuoli R. Generating memory with vaccination. Eur J Immunol 2009; 39(8):2100-5. [DOI] [PMID]
17. Wu CJ, Ko HC, Lee HC, Tsai WC, Li MG, Pao YZ, et al. Decline of tetanus antitoxin level with age in taiwan. J Formos Med Assoc 2009; 108(5):395-401. [DOI] [PMID]
18. Alagappan K, Rennie W, Kwiatkowski T, Falck J, Silverstone F, Silverman R. Seroprevalence of tetanus antibodies among adults older than 65 years. Ann Emerg Med 1996; 28(1):18-21. [DOI] [PMID]
19. Nemati M, Zarrin M, Mir-Abdollah SA, Rezayati MT, Mirzaee V, Bagheri A, et al. Lower serum level of anti-tetanus toxin antibodies in patients with type 2 diabetes mellitus. Acta Med Indones 2014; 46(1):44-50. [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
