Journal of Occupational
Health and Epidemiology
Rafsanjan university Of medical sciences
Volume 14, Issue 4 (Autumn 2025)
J Occup Health Epidemiol 2025, 14(4): 268-279 |
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Fouladi Dehaghi B, Tabanfar S, Sobhani S. Impact of Low-Dose Ionizing Radiation on Liver Function in Mice: A Systematic Review. J Occup Health Epidemiol 2025; 14 (4) :268-279
URL: http://johe.rums.ac.ir/article-1-1020-en.html
URL: http://johe.rums.ac.ir/article-1-1020-en.html
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1- Professor, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ,sobhani.s@ajums.ac.ir
2- Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ,
Article history
Received: 2025/02/11
Accepted: 2025/05/22
ePublished: 2025/12/13
Accepted: 2025/05/22
ePublished: 2025/12/13
Subject:
Epidemiology
Abstract: (30 Views)
Background: Adverse health consequences of exposure to ionizing radiation, especially low-dose radiation (LDR), are highly controversial. Recent studies have shown that ionizing radiation can promote the inflammatory state of the liver. The present study aimed to review the current knowledge of the harmful effects of low-dose ionizing radiation on the liver in mice.
Materials and Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science (WOS) databases. The PRISMA protocol was employed for systematic literature review, which includes formulation of research questions, systematic review process for selection of articles, quality assessment, data abstraction, and data analysis.
Results: In the first stage of the systematic review process, 1473 articles were retrieved. At last a total of 15 articles were included in the study based on the inclusion and exclusion criteria. LDR from X-rays and gamma rays was utilized for irradiation in these articles. The results revealed that low-dose ionizing radiation can have detrimental effects, including mitochondrial dysfunction, increased oxidative stress, dilation of the central hepatic vein, increased expression of hepatic proteins involved in metabolism, liver inflammation, necrosis, and cancer in the liver.
Conclusion: Given the potentially damaging effects of low-dose ionizing radiation exposure to the liver, early identification of individuals at higher risk of exposure to these radiations can result in better preventive intervention decisions to prevent damage.
Materials and Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science (WOS) databases. The PRISMA protocol was employed for systematic literature review, which includes formulation of research questions, systematic review process for selection of articles, quality assessment, data abstraction, and data analysis.
Results: In the first stage of the systematic review process, 1473 articles were retrieved. At last a total of 15 articles were included in the study based on the inclusion and exclusion criteria. LDR from X-rays and gamma rays was utilized for irradiation in these articles. The results revealed that low-dose ionizing radiation can have detrimental effects, including mitochondrial dysfunction, increased oxidative stress, dilation of the central hepatic vein, increased expression of hepatic proteins involved in metabolism, liver inflammation, necrosis, and cancer in the liver.
Conclusion: Given the potentially damaging effects of low-dose ionizing radiation exposure to the liver, early identification of individuals at higher risk of exposure to these radiations can result in better preventive intervention decisions to prevent damage.
Keywords: Ionizing Radiation [MeSH], Low-Dose Radiation , Mice [MeSH], Gamma Rays [MeSH], X-Rays [MeSH], Oxidative Stress [MeSH]
References
1. Dahl H, Ballangby J, Tengs T, Wojewodzic MW, Eide DM, Brede DA, et al. Dose rate dependent reduction in chromatin accessibility at transcriptional start sites long time after exposure to gamma radiation. Epigenetics. 2023;18(1):2193936. [DOI] [PMID] [PMCID]
2. Bakshi MV, Azimzadeh O, Barjaktarovic Z, Kempf SJ, Merl-Pham J, Hauck SM, et al. Total body exposure to low-dose ionizing radiation induces long-term alterations to the liver proteome of neonatally exposed mice. J Proteome Res. 2015;14(1):366-73. [DOI] [PMID]
3. Reisz JA, Bansal N, Qian J, Zhao W, Furdui CM. Effects of ionizing radiation on biological molecules—mechanisms of damage and emerging methods of detection. Antioxid Redox Signal. 2014;21(2):260-92. [DOI] [PMID] [PMCID]
4. Łysek-Gładysińska M, Wieczorek A, Walaszczyk A, Jelonek K, Pietrowska M, Widłak P, et al. Late Effects of Ionizing Radiation on the Ultrastructure of Hepatocytes and Activity of Lysosomal Enzymes in Mouse Liver Irradiated In Vivo. Metabolites. 2024;14(4):212. [DOI] [PMID] [PMCID]
5. Ristow M. Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits. Nat Med. 2014;20(7):709-11. [DOI] [PMID]
6. Azzam EI, Jay-Gerin JP, Pain D. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett. 2012;327(1-2):48-60. [DOI] [PMID] [PMCID]
7. Jang WG, Park JY, Lee J, Bang E, Kim SR, Lee EK, et al. Investigation of relative metabolic changes in the organs and plasma of rats exposed to X-ray radiation using HR-MAS (1)H NMR and solution (1)H NMR. NMR Biomed. 2016;29(4):507-18. [DOI] [PMID]
8. Zhang Y, Humes F, Almond G, Kavazis AN, Hood WR. A mitohormetic response to pro-oxidant exposure in the house mouse. Am J Physiol Regul Integr Comp Physiol. 2018;314(1):R122-34. [DOI] [PMID] [PMCID]
9. Dahl H, Eide DM, Tengs T, Duale N, Kamstra JH, Oughton DH, et al. Perturbed transcriptional profiles after chronic low dose rate radiation in mice. PLoS One. 2021;16(8):e0256667. [DOI] [PMID] [PMCID]
10. Yi L, Li L, Yin J, Hu N, Li G, Ding D. Proteomics analysis of liver tissues from C57BL/6J mice receiving low-dose 137 Cs radiation. Environ Sci Pollut Res Int. 2016;23(3):2549-56. [DOI] [PMID]
11. Morgan WF, Bair WJ. Issues in low dose radiation biology: the controversy continues. A perspective. Radiat Res. 2013;179(5):501-10. [DOI] [PMID]
12. Liang X, Zheng S, Cui J, Yu D, Yang G, Zhou L, et al. Alterations of microRNA expression in the liver, heart, and testis of mice upon exposure to repeated low-dose radiation. Dose Response. 2018;16(3):1559325818799561. [DOI] [PMID] [PMCID]
13. Dawson LA, Normolle D, Balter JM, McGinn CJ, Lawrence TS, Ten Haken RK. Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys. 2002;53(4):810-21. [DOI] [PMID]
14. Suzuki K, Imaoka T, Tomita M, Sasatani M, Doi K, Tanaka S, et al. Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. Part II: Hematopoietic system, lung and liver. J Radiat Res. 2023;64(2):228-49. [DOI] [PMID] [PMCID]
15. Gridley DS, Mao XW, Cao JD, Bayeta EJ, Pecaut MJ. Protracted low-dose radiation priming and response of liver to acute gamma and proton radiation. Free Radic Res. 2013;47(10):811-20. [DOI] [PMID]
16. Abdel-Aziz N, Haroun RA, Mohamed HE. Low-dose gamma radiation modulates liver and testis tissues response to acute whole body irradiation. Dose Response. 2022;20(2):15593258221092365. [DOI] [PMID] [PMCID]
17. Marra F, Tacke F. Roles for chemokines in liver disease. Gastroenterology. 2014;147(3):577-94. e1. [DOI] [PMID]
18. Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162(11):777-84. [DOI] [PMID]
19. Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43. [DOI] [PMID] [PMCID]
20. Mikhailov VF, Saleeva DV, Rozhdestvensky LM, Shulenina LV, Raeva NF, Zasukhina GD. Activity of genes and noncoding RNAs as an approach to determination of early biomarkers of radiation-induced cancer in mice. Russ J Genet. 2021;57:1140-8. [DOI]
21. Nakajima T, Wang B, Ono T, Uehara Y, Nakamura S, Ichinohe K, et al. Differences in sustained alterations in protein expression between livers of mice exposed to high-dose-rate and low-dose-rate radiation. J Radiat Res. 2017;58(4):421-9. [DOI] [PMID] [PMCID]
22. Yi L, Mu H, Hu N, Sun J, Yin J, Dai K, et al. Differential expression of NPM, GSTA3, and GNMT in mouse liver following long-term in vivo irradiation by means of uranium tailings. Biosci Rep. 2018;38(5):BSR20180536. [DOI] [PMID] [PMCID]
23. Davidson CQ, Tharmalingam S, Niccoli S, Nemec-Bakk A, Khurana S, Murray A, et al. Dose threshold for radiation induced fetal programming in a mouse model at 4 months of age: Hepatic expression of genes and proteins involved in glucose metabolism and glucose uptake in brown adipose tissue. PLoS One. 2020;15(4):e0231650. [DOI] [PMID] [PMCID]
24. Saad WMM, Mohammad MKA, Mohamed MI, Razak HRA. Enhancement of Oxidative DNA Damage and Alteration of p53, Bax, and Bcl-2 Protein Expressions Following Low Dose Radiation Exposure. Pertanika J Sci Technol. 2017;25:41-52.
25. Lysek-Gladysinska M, Wieczorek A, Walaszczyk A, Jelonek K, Jozwik A, Pietrowska M, et al. Long-term effects of low-dose mouse liver irradiation involve ultrastructural and biochemical changes in hepatocytes that depend on lipid metabolism. Radiat Environ Biophys. 2018;57(2):123-32. [DOI] [PMID]
26. Fujikawa K, Sugihara T, Tanaka S, Tanaka I, Nakamura S, Nakamura-Murano M, et al. Low dose-rate radiation-specific alterations found in a genome-wide gene expression analysis of the mouse liver. Radiat Prot Dosimetry. 2022;198(13-15):1165-9. [DOI] [PMID]
27. Tanaka IB 3rd, Komura J, Tanaka S. Pathology of serially sacrificed female B6C3F1 mice continuously exposed to very low-dose-rate gamma rays. Radiat Res. 2017;187(3):346-60. [DOI] [PMID]
28. Esplugas R, LLovet MI, Bellés M, Serra N, Vallvé JC, Domingo JL, et al. Renal and hepatic effects following neonatal exposure to low doses of Bisphenol-A and 137Cs. Food Chem Toxicol. 2018;114:270-7. [DOI] [PMID]
29. Nicolas F, Wu C, Bukhari S, de Toledo SM, Li H, Shibata M, et al. S-Nitrosylation in Organs of Mice Exposed to Low or High Doses of γ-Rays: The Modulating Effect of Iodine Contrast Agent at a Low Radiation Dose. Proteomes. 2015;3(2):56-73. [DOI] [PMID] [PMCID]
30. Jafer A, Sylvius N, Adewoye AB, Dubrova YE. The long-term effects of exposure to ionising radiation on gene expression in mice. Mutat Res. 2020;821:111723. [DOI] [PMID]
31. Yi L, Hu N, Yin J, Sun J, Mu H, Dai K, et al. Up-regulation of calreticulin in mouse liver tissues after long-term irradiation with low-dose-rate gamma rays. PLoS One. 2017;12(9):e0182671. [DOI] [PMID] [PMCID]
32. Kojima S, Tsukimoto M, Shimura N, Koga H, Murata A, Takara T. Treatment of cancer and inflammation with low-dose ionizing radiation: three case reports. Dose Response. 2017;15(1):1559325817697531. [DOI] [PMID] [PMCID]
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