Journal of Occupational
Health and Epidemiology
Rafsanjan university Of medical sciences
Volume 14, Issue 4 (Autumn 2025)
J Occup Health Epidemiol 2025, 14(4): 268-279 |
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Fouladi Dehaghi B, Tabanfar S, Sobhani S. Impact of Low-Dose Ionizing Radiation on Liver Function in Mice: A Systematic Review. J Occup Health Epidemiol 2025; 14 (4) :268-279
URL: http://johe.rums.ac.ir/article-1-1020-en.html
URL: http://johe.rums.ac.ir/article-1-1020-en.html
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1- Professor, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ,sobhani.s@ajums.ac.ir
2- Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Ph.D. Student in Occupational Health and Safety, Dept. of Occupational Safety and Health Engineering, Faculty of Health, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ,
Article history
Received: 2025/02/11
Accepted: 2025/05/22
ePublished: 2025/12/13
Accepted: 2025/05/22
ePublished: 2025/12/13
Subject:
Epidemiology
Abstract: (31 Views)
Background: Adverse health consequences of exposure to ionizing radiation, especially low-dose radiation (LDR), are highly controversial. Recent studies have shown that ionizing radiation can promote the inflammatory state of the liver. The present study aimed to review the current knowledge of the harmful effects of low-dose ionizing radiation on the liver in mice.
Materials and Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science (WOS) databases. The PRISMA protocol was employed for systematic literature review, which includes formulation of research questions, systematic review process for selection of articles, quality assessment, data abstraction, and data analysis.
Results: In the first stage of the systematic review process, 1473 articles were retrieved. At last a total of 15 articles were included in the study based on the inclusion and exclusion criteria. LDR from X-rays and gamma rays was utilized for irradiation in these articles. The results revealed that low-dose ionizing radiation can have detrimental effects, including mitochondrial dysfunction, increased oxidative stress, dilation of the central hepatic vein, increased expression of hepatic proteins involved in metabolism, liver inflammation, necrosis, and cancer in the liver.
Conclusion: Given the potentially damaging effects of low-dose ionizing radiation exposure to the liver, early identification of individuals at higher risk of exposure to these radiations can result in better preventive intervention decisions to prevent damage.
Materials and Methods: A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science (WOS) databases. The PRISMA protocol was employed for systematic literature review, which includes formulation of research questions, systematic review process for selection of articles, quality assessment, data abstraction, and data analysis.
Results: In the first stage of the systematic review process, 1473 articles were retrieved. At last a total of 15 articles were included in the study based on the inclusion and exclusion criteria. LDR from X-rays and gamma rays was utilized for irradiation in these articles. The results revealed that low-dose ionizing radiation can have detrimental effects, including mitochondrial dysfunction, increased oxidative stress, dilation of the central hepatic vein, increased expression of hepatic proteins involved in metabolism, liver inflammation, necrosis, and cancer in the liver.
Conclusion: Given the potentially damaging effects of low-dose ionizing radiation exposure to the liver, early identification of individuals at higher risk of exposure to these radiations can result in better preventive intervention decisions to prevent damage.
Keywords: Ionizing Radiation [MeSH], Low-Dose Radiation , Mice [MeSH], Gamma Rays [MeSH], X-Rays [MeSH], Oxidative Stress [MeSH]
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